Guideline for Reversal of Antithrombotics in Intracranial Hemorrhage
| Autor: | Monisha A. Kumar, John J. Lewin, Cindy L. Zerfoss, Gregory J. del Zoppo, Ellinor I.B. Peerschke, Katja E. Wartenberg, Alejandro A. Rabinstein, Jeanne Teitelbaum, Aaron M. Cook, Michael F. Stiefel, Jennifer A. Frontera, Imo P. Aisiku, Anne W. Alexandrov |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Critical Care Pharmacy 030204 cardiovascular system & hematology Critical Care and Intensive Care Medicine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Fibrinolytic Agents Edoxaban Humans Medicine Intensive care medicine Intraparenchymal hemorrhage Societies Medical Intracerebral hemorrhage Rivaroxaban business.industry Neurointensive care Guideline medicine.disease Neurology chemistry Direct thrombin inhibitor Practice Guidelines as Topic Neurology (clinical) business Intracranial Hemorrhages 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neurocritical Care. 24:6-46 |
| ISSN: | 1556-0961 1541-6933 |
| DOI: | 10.1007/s12028-015-0222-x |
| Popis: | The use of antithrombotic agents, including anticoagulants, antiplatelet agents, and thrombolytics has increased over the last decade and is expected to continue to rise. Although antithrombotic-associated intracranial hemorrhage can be devastating, rapid reversal of coagulopathy may help limit hematoma expansion and improve outcomes. The Neurocritical Care Society, in conjunction with the Society of Critical Care Medicine, organized an international, multi-institutional committee with expertise in neurocritical care, neurology, neurosurgery, stroke, hematology, hemato-pathology, emergency medicine, pharmacy, nursing, and guideline development to evaluate the literature and develop an evidence-based practice guideline. Formalized literature searches were conducted, and studies meeting the criteria established by the committee were evaluated. Utilizing the GRADE methodology, the committee developed recommendations for reversal of vitamin K antagonists, direct factor Xa antagonists, direct thrombin inhibitors, unfractionated heparin, low-molecular weight heparin, heparinoids, pentasaccharides, thrombolytics, and antiplatelet agents in the setting of intracranial hemorrhage. This guideline provides timely, evidence-based reversal strategies to assist practitioners in the care of patients with antithrombotic-associated intracranial hemorrhage. |
| Databáze: | OpenAIRE |
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