Chitosan Based Self-Assembled Nanoparticles in Drug Delivery
| Autor: | Hazel Peniche, Javier Pérez Quiñones, Carlos Peniche |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Drug
Biodistribution Polymers and Plastics media_common.quotation_subject Nanoparticle 02 engineering and technology macromolecular substances Review 010402 general chemistry polyelectrolyte complex 01 natural sciences Micelle Chitosan lcsh:QD241-441 chemistry.chemical_compound Chitin lcsh:Organic chemistry media_common nanoparticle other technology industry and agriculture General Chemistry 021001 nanoscience & nanotechnology Combinatorial chemistry Polyelectrolyte 0104 chemical sciences carbohydrates (lipids) self-assembled chemistry Drug delivery drug delivery chitosan 0210 nano-technology |
| Zdroj: | Polymers Polymers, Vol 10, Iss 3, p 235 (2018) |
| ISSN: | 2073-4360 |
| Popis: | Chitosan is a cationic polysaccharide usually obtained by alkaline deacetylation of chitin poly(N-acetylglucosamine). It is biocompatible, biodegradable, mucoadhesive and non-toxic. These excellent biological properties make chitosan a good candidate as platform for developing drug delivery systems with improved biodistribution, increased specificity and sensitivity, and reduced pharmacological toxicity. In particular, chitosan nanoparticles have been found appropriate for non-invasive routes of drug administration: oral, nasal, pulmonary and ocular routes. These applications are facilitated by the absorption-enhancing effect of chitosan. Many different procedures have been proposed for obtaining chitosan nanoparticles. Particularly, the introduction of hydrophobic moieties into chitosan molecules by grafting to generate a hydrophobic-hydrophilic balance promoting self-assembling is a current and appealing approach. The grafting agent can be a hydrophobic moiety to form micelles that can entrap lipophilic drugs or it can be the drug itself. Another suitable way to generate self-assembled chitosan nanoparticles is through the formation of polyelectrolyte complexes with polyanions. This paper reviews the main approaches developed for preparing chitosan nanoparticles by self-assembling by both procedures and illustrates the state of the art of their application in drug delivery. |
| Databáze: | OpenAIRE |
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