Erratum to: FoundationOne CDx testing accurately determines whole arm 1p19q codeletion status in gliomas
| Autor: | Albert Lai, Timothy F. Cloughesy, James Haberberger, Jacqueline Jenkins, Natalie Danziger, Lee A. Albacker, William H. Yong, Maureen Cooper, Brian M. Alexander, Phioanh L. Nghiemphu, Dean Pavlick, Matthew Ji, Linda M. Liau, Garrett M. Frampton, Shakti Ramkissoon, Radwa Sharaf |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Neuro-oncology Advances Neuro-oncology advances, vol 3, iss 1 |
| ISSN: | 2632-2498 |
| Popis: | Molecular profiling of gliomas is vital to ensure diagnostic accuracy, inform prognosis, and identify clinical trial options for primary and recurrent tumors. This study aimed to determine the accuracy of reporting the whole arm 1p19q codeletion status from the FoundationOne platform.Testing was performed on glioma samples as part of clinical care and analyzed up to 395 cancer-associated genes (includingConcordance between 1p19q status based on FISH and our algorithm was 96.7% (449/463) with a positive predictive value (PPV) of 100% and a positive percent agreement (PPA) of 91.0%. All discordant samples were positive for codeletion by FISH and harbored genomic alterations inconsistent with oligodendrogliomas. Median overall survival was 168 months for the1p19q codeletion status derived from FoundationOne testing is highly concordant with FISH results. Genomic profiling may be a reliable substitute for traditional FISH testing while also providing |
| Databáze: | OpenAIRE |
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