Association of cancer awareness levels with the risk of cancer in rural China: A population‐based cohort study

Autor: Xiaonong Zou, Xiaoqin Cao, Xibin Sun, Shangchun Jia, Jialin Wang, Wanqing Chen, Lei Fan, Jinyi Zhou, Zhenqiu Zha, Rongshou Zheng, Maomao Cao, Jufang Shi, Pengfei Luo, Hongmei Zeng, He Li, Dianqin Sun, Hengmin Ma, Shixian Feng
Rok vydání: 2020
Předmět:
Zdroj: Cancer. 126:4563-4571
ISSN: 1097-0142
0008-543X
Popis: BACKGROUND Evidence of the effects of cancer prevention knowledge on the risk of developing cancer remains scarce. The objective of this study was to prospectively examine the association of cancer prevention awareness levels with cancer risk in a population-based cancer screening cohort in China. METHODS This prospective cohort study included 164,341 participants aged 40 to 69 years with no history of cancer and with available information on cancer prevention core knowledge in the Esophageal, Stomach, and Liver Cancer Screening Program. Participants were recruited from 18 rural regions across 4 provinces in China from 2007 to 2014 and were followed until December 31, 2015. The core knowledge of cancer prevention content included 9 items, with a total score ranging from 0 to 100. Cox proportional hazards regression models and restricted cubic spline analysis were used to estimate hazard ratios and 95% CIs. RESULTS High cancer prevention knowledge scores were inversely associated with the overall risk of cancer (group 4 vs group 1: hazard ratio, 0.669; 95% CI, 0.576-0.776). Subgroup analysis showed that this inverse association could be observed in women, participants with lower educational or income levels, and those without a family history of cancer. Restricted cubic spline analysis exhibited a nonlinear (L-shaped) relation between cancer knowledge scores and cancer risk (overall P
Databáze: OpenAIRE
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