A new MRI rating scale for progressive supranuclear palsy and multiple system atrophy: validity and reliability
| Autor: | Rolland, Yan, Vérin, Marc, Payan, Christine, Duchesne, Simon, Kraft, Eduard, Hauser, Till, Jarosz, Josef, Deasy, Neil, Defevbre, Luc, Delmaire, Christine, Dormont, Didier, Ludolph, Albert, Bensimon, Gilbert, Leigh, Nigel, Grand, Sylvie |
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| Přispěvatelé: | Service d'Imagerie Médicale, CRLCC Eugène Marquis (CRLCC), Service de Neurologie [Rennes] = Neurology [Rennes], CHU Pontchaillou [Rennes], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de Radiologie, Université Laval [Québec] (ULaval)-Centre de Recherche Robert Giffard, Service de Neurologie, Universität Ulm - Ulm University [Ulm, Allemagne], Service de Neuroradiologie, Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen, Brighton and Sussex Medical School (BSMS)-Trafford Centre for Biomedical Research-University of Sussex, Department of Clinical Neuroscience, Queen Mary University of London (QMUL)-King‘s College London-MRC Centre for Neurodegeneration Research-KCL Institute of Psychiatry, Service de neurologie et pathologie du mouvement, Hôpital Roger Salengro [Lille]-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Services de neuroradiologie [Lille], Service de Neuroradiologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), ANTE-INSERM U836, équipe 5, Neuroimagerie fonctionnelle et perfusion cérébrale, Département de radiologie et d'imagerie médicale, CHU Grenoble-CHU Grenoble, European Union 5th Framework programme (QLG1-CT-2000-01262, French Health Ministry, Programme Hospitalier de Recherche Clinique (AOM97073, AOM01125), Sanofi-Aventis, Fonds pour la Recherche en Sante' du Québec, NNIPPS Study Group, Service de Neurologie [Rennes], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Queen Mary University of London (QMUL)-MRC Centre for Neurodegeneration Research-KCL Institute of Psychiatry-King‘s College London, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université, Dojat, Michel |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
Pathology MESH: Multiple System Atrophy 610 Medizin Validity MESH: Observer Variation Basal Ganglia 030218 nuclear medicine & medical imaging MESH: Magnetic Resonance Imaging MESH: Basal Ganglia 0302 clinical medicine MESH: Aged 80 and over Mesencephalon Cerebellum Pons Image Processing Computer-Assisted MESH: Neurologic Examination Cluster Analysis Age of Onset MESH: Aged Aged 80 and over Neurologic Examination Observer Variation ddc:610 Principal Component Analysis MESH: Middle Aged medicine.diagnostic_test Brain Middle Aged MESH: Image Processing Computer-Assisted Magnetic Resonance Imaging 3. Good health MESH: Reproducibility of Results Psychiatry and Mental health [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Female Supranuclear Palsy Progressive Psychology Research Paper Predictive validity Adult medicine.medical_specialty MESH: Socioeconomic Factors MESH: Age of Onset Context (language use) Progressive supranuclear palsy 03 medical and health sciences MESH: Brain Atrophy Cronbach's alpha Rating scale medicine Humans [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Aged MESH: Principal Component Analysis MESH: Humans business.industry MESH: Pons Reproducibility of Results Magnetic resonance imaging MESH: Adult MESH: Mesencephalon Multiple System Atrophy medicine.disease MESH: Cluster Analysis MESH: Male MESH: Cerebellum MESH: Cranial Fossa Posterior Cranial Fossa Posterior Socioeconomic Factors MESH: Supranuclear Palsy Progressive Surgery Neurology (clinical) Nuclear medicine business MESH: Female 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neurology, Neurosurgery, and Psychiatry Journal of Neurology, Neurosurgery and Psychiatry Journal of Neurology, Neurosurgery and Psychiatry, BMJ Publishing Group, 2011, 82 (9), pp.1025-32. ⟨10.1136/jnnp.2010.214890⟩ Journal of Neurology, Neurosurgery and Psychiatry, 2011, 82 (9), pp.1025-32. ⟨10.1136/jnnp.2010.214890⟩ |
| ISSN: | 1468-330X 0022-3050 |
| DOI: | 10.1136/jnnp.2010.214890⟩ |
| Popis: | GB and PNL contributed equally to this paper.; International audience; AIM: To evaluate a standardised MRI acquisition protocol and a new image rating scale for disease severity in patients with progressive supranuclear palsy (PSP) and multiple systems atrophy (MSA) in a large multicentre study. METHODS: The MRI protocol consisted of two-dimensional sagittal and axial T1, axial PD, and axial and coronal T2 weighted acquisitions. The 32 item ordinal scale evaluated abnormalities within the basal ganglia and posterior fossa, blind to diagnosis. Among 760 patients in the study population (PSP = 362, MSA = 398), 627 had per protocol images (PSP = 297, MSA = 330). Intra-rater (n = 60) and inter-rater (n = 555) reliability were assessed through Cohen's statistic, and scale structure through principal component analysis (PCA) (n = 441). Internal consistency and reliability were checked. Discriminant and predictive validity of extracted factors and total scores were tested for disease severity as per clinical diagnosis. RESULTS: Intra-rater and inter-rater reliability were acceptable for 25 (78%) of the items scored (≥ 0.41). PCA revealed four meaningful clusters of covarying parameters (factor (F) F1: brainstem and cerebellum; F2: midbrain; F3: putamen; F4: other basal ganglia) with good to excellent internal consistency (Cronbach α 0.75-0.93) and moderate to excellent reliability (intraclass coefficient: F1: 0.92; F2: 0.79; F3: 0.71; F4: 0.49). The total score significantly discriminated for disease severity or diagnosis; factorial scores differentially discriminated for disease severity according to diagnosis (PSP: F1-F2; MSA: F2-F3). The total score was significantly related to survival in PSP (p |
| Databáze: | OpenAIRE |
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