Reproducibility of serial optical coherence tomography measurements for lumen area and plaque components in humans (The CLI-VAR [Centro per la Lotta Contro l'Infarto-variability] II study)
| Autor: | Andrea Mangiameli, Francesco Prati, Silvio Fedele, Enrico Romagnoli, Laura Gatto, Giulia Paoletti, Luca Di Vito, Valeria Marco, Fausto Castriota, Vito Ramazzotti, Andrea Ricciardi |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Pathology medicine.medical_specialty Rome Coronary Artery Disease 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Optical coherence tomography In vivo Predictive Value of Tests Medicine Humans Radiology Nuclear Medicine and imaging 030212 general & internal medicine Prospective Studies Cardiac imaging Aged Reproducibility Cardiac cycle medicine.diagnostic_test business.industry Fibrous cap Reproducibility of Results Middle Aged Coronary Vessels Fibrosis Lipids Plaque Atherosclerotic medicine.anatomical_structure Disease Progression Female Core laboratory Cardiology and Cardiovascular Medicine business Nuclear medicine Tomography Optical Coherence Lumen (unit) |
| Zdroj: | The international journal of cardiovascular imaging. 32(3) |
| ISSN: | 1875-8312 |
| Popis: | Frequency-domain optical coherence tomography (FD-OCT) is a promising intracoronary imaging technique to study atherosclerosis. Indeed, its unprecedented spatial resolution allows the assessment of fibrous cap thickness, lipid pool and features of plaque vulnerability. Aim of this study was to determine the reproducibility of the in vivo FD-OCT measurements of lumen area and plaque components in serial studies. Twenty-six patients undergoing FD-OCT assessment of intermediate lesion during coronary angiography were included in this study. FD-OCT pullbacks were acquired twice from the same coronary segment at interval of 5 min without additional intervention and analyzed off-line at an independent imaging core laboratory. Lumen diameter (LD), lumen area (LA), fibrous cap (FC) thickness and lipid pool (LP) arc extension measurements were compared in 440 matched frames. Both the per-segment and per-frame analyses showed excellent correlation coefficients for the inter-pullback comparisons for all parameters explored (R > 0.95 and p |
| Databáze: | OpenAIRE |
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