Hepatoblastoma: A Need for Cell Lines and Tissue Banks to Develop Targeted Drug Therapies
| Autor: | Lisa Easom Howard, Michael S. Bateman, Max Bateman, Rishi Raj Rikhi, Ruth I. Hoffman, Kimberlee K. Spady |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Drug Poor prognosis Hepatoblastoma medicine.medical_specialty media_common.quotation_subject Donated tissue cell lines Pediatrics Tissue procurement 03 medical and health sciences 0302 clinical medicine medicine roadmap Intensive care medicine tissue procurement media_common business.industry lcsh:RJ1-570 lcsh:Pediatrics hepatoblastoma medicine.disease digestive system diseases 030104 developmental biology 030220 oncology & carcinogenesis Tissue bank Pediatrics Perinatology and Child Health Immunology Perspective xenograft models business |
| Zdroj: | Frontiers in Pediatrics, Vol 4 (2016) Frontiers in Pediatrics |
| ISSN: | 2296-2360 |
| DOI: | 10.3389/fped.2016.00022 |
| Popis: | Limited research exists regarding the most aggressive forms of hepatoblastoma. Cell lines of the rare subtypes of hepatoblastoma with poor prognosis are not only difficult to attain but also challenging to characterize histologically. A community-driven approach to educating parents and families, regarding the need for donated tissue, is necessary for scientists to have access to resources for murine models and drug discovery. Herein, we describe the currently available resources, existing gaps in research, and the path to move forward for uniform cure of hepatoblastoma. |
| Databáze: | OpenAIRE |
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