Effect ofArgania spinosaoil extract on proliferation and Notch1 and ERK1/2 signaling of T-cell acute lymphoblastic leukemia cell lines
| Autor: | Zahia Kabouche, Sakina Zerizer, Boutheyna Aribi, Rocco Palermo, Isabella Screpanti |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Antioxidant medicine.diagnostic_test Traditional medicine medicine.medical_treatment Immunology food and beverages Context (language use) Biology biology.organism_classification Sapotaceae Jurkat cells Endosperm 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Biochemistry Western blot 030220 oncology & carcinogenesis medicine anti-proliferative effect Argania spinosa oil extract ERK1/2 leukemia cell lines Notch1 MTT assay Cytotoxicity Agronomy and Crop Science Food Science |
| Zdroj: | Food and Agricultural Immunology. 27:350-357 |
| ISSN: | 1465-3443 0954-0105 |
| Popis: | The Argan tree, called Argania spinosa (L.) Skeels, is a tropical plant, which belongs to the Sapotaceae family, it is exploited essentially for its fruits. The endosperm seed of the fruit constitutes a good potential source of edible oil for human consumption and is endowed with important medicinal properties such as antioxidant, antimalarial and anti-proliferative. The aim of the present work is to evaluate the anti-proliferative effect of the oil extracted from seeds of A. spinosa in T-cell acute lymphoblastic leukemia human (T-ALL) context. The activity was assessed through an in vitro test on three T-ALL cell lines: JURKAT, MOLT3 and DND41. The cytotoxicity effects of A. spinosa oil extract were checked by MTT assay and the change in the activity levels of two T-ALL proliferation-related proteins (Notch1 and ERK) was investigated by Western blot, the results demonstrate that treatment with A. spinosa oil extract at the dose of 100 μg/mL inhibited the growth of JURKAT, MOLT3 and DND41 cells, a... |
| Databáze: | OpenAIRE |
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