Proposal for assignment of allele numbers for mobile colistin resistance (mcr) genes
| Autor: | Basil Britto Xavier, Michael Feldgarden, Jianzhong Shen, Arjun B. Prasad, Yang Wang, Surbhi Malhotra-Kumar, Vincenzo Di Pilato, Samir Kumar-Singh, William Klimke, Yohei Doi, Gian Maria Rossolini, Stefan Schwarz, Timothy R. Walsh, Jian-Hua Liu, Daniel H. Haft, Sally R. Partridge |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Microbiology (medical) 030106 microbiology Microbial Sensitivity Tests Biology beta-Lactamases Colistin resistance 03 medical and health sciences Terminology as Topic Drug Resistance Bacterial medicine Escherichia coli Pharmacology (medical) Allele Gene Nomenclature Alleles Confusion Pharmacology Genetics Whole genome sequencing For Debate Bacteria Whole Genome Sequencing Colistin Pharmacology. Therapy Escherichia coli Proteins Anti-Bacterial Agents Gene nomenclature Infectious Diseases Human medicine medicine.symptom Genes MDR hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy The journal of antimicrobial chemotherapy |
| ISSN: | 0305-7453 |
| DOI: | 10.1093/jac/dky262 |
| Popis: | The initial report of the mcr-1 (mobile colistin resistance) gene has led to many reports of mcr-1 variants and other mcr genes from different bacterial species originating from human, animal and environmental samples in different geographical locations. Resistance gene nomenclature is complex and unfortunately problems such as different names being used for the same gene/protein or the same name being used for different genes/proteins are not uncommon. Registries exist for some families, such as bla (ii-lactamase) genes, but there is as yet no agreed nomenclature scheme for mcr genes. The National Center for Biotechnology Information (NCBI) recently took over assigning bla allele numbers from the longstanding Lahey p-ractamase website and has agreed to do the same for mcr genes. Here, we propose a nomenclature scheme that we hope will be acceptable to researchers in this area and that will reduce future confusion. |
| Databáze: | OpenAIRE |
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