Reconstructing Genetic History of Siberian and Northeastern European Populations
Autor: | James A. Knowles, Emily H. M. Wong, Svetlana A. Limborska, Denis Khokhrin, Anton Valouev, Andrey Khrunin, Oleg V. Evgrafov, Larissa Nichols, John Novembre, Dmitry Pushkarev, Dmitry A. Verbenko |
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Rok vydání: | 2015 |
Předmět: |
Gene Flow
0301 basic medicine Sequencing data Ethnic group Biology DNA Mitochondrial White People Indigenous Russia Gene flow 03 medical and health sciences Asian People Genetic variation Ethnicity Genetics Humans East Asia Genetics (clinical) 030304 developmental biology 0303 health sciences Genome Human Research 030305 genetics & heredity Genetic Variation High-Throughput Nucleotide Sequencing 15. Life on land Samara Siberia Eastern european Phylogeography Genetics Population 030104 developmental biology Geography Haplotypes Evolutionary biology Ethnology Human genome |
Popis: | Siberia and Northwestern Russia are home to over 40 culturally and linguistically diverse indigenous ethnic groups, yet genetic variation and histories of peoples from this region are largely uncharacterized. We present deep whole-genome sequencing data (∼38×) from 28 individuals belonging to 14 distinct indigenous populations from that region. We combined these data sets with additional 32 modern-day and 46 ancient human genomes to reconstruct genetic histories of several indigenous Northern Eurasian populations. We found that Siberian and East Asian populations shared 38% of their ancestry with a 45,000-yr-old Ust’-Ishim individual who was previously believed to have no modern-day descendants. Western Siberians trace 57% of their ancestry to ancient North Eurasians, represented by the 24,000-yr-old Siberian Mal'ta boy MA-1. Eastern Siberian populations formed a distinct sublineage that separated from other East Asian populations ∼10,000 yr ago. In addition, we uncovered admixtures between Siberians and Eastern European hunter-gatherers from Samara, Karelia, Hungary, and Sweden (from 8000–6600 yr ago); Yamnaya people (5300–4700 yr ago); and modern-day Northeastern Europeans. Our results provide new insights into genetic histories of Siberian and Northeastern European populations and evidence of ancient gene flow from Siberia into Europe. |
Databáze: | OpenAIRE |
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