Interaction of methyl-xanthines with myeloperoxidase. An anti-inflammatory mechanism
| Autor: | Ben J. van der Walt, Johann M. van Zyl, André Kriegler |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Hypochlorous acid
medicine.drug_class Stereochemistry Biochemistry Anti-inflammatory Catalysis Structure-Activity Relationship chemistry.chemical_compound medicine Humans Theobromine Peroxidase chemistry.chemical_classification biology Spectrum Analysis Anti-Inflammatory Agents Non-Steroidal NAD Xanthine Hypochlorous Acid Enzyme chemistry Xanthines Myeloperoxidase biology.protein Caffeine Oxidation-Reduction medicine.drug |
| Zdroj: | International Journal of Biochemistry. 24:929-935 |
| ISSN: | 0020-711X |
| DOI: | 10.1016/0020-711x(92)90099-m |
| Popis: | 1. 1. Inhibition of myeloperoxidase (MPO)-catalyzed reactions by methyl-substituted xanthines has been investigated. 2. 2. Except for theobromine and caffeine, all xanthines tested were potent inhibitors of the MPO-H 2 O 2 -Cl − system. 3. 3. In contrast to methyl substitution in the 1 or 8 position of xanthine, substitution in the 3 or 7 position had a marked effect on the inhibition of MPO catalysis. 4. 4. Two different inhibitory mechanisms were induced; scavenging of hypochlorous acid (HOCl) generated by the MPO system and accumulation of Compound II (ferryl MPO) which is inactive as a catalyst of Cl − oxidation. |
| Databáze: | OpenAIRE |
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