A critical role for interleukin-1 receptor accessory protein in interleukin-1 signaling
| Autor: | Christian Korherr, Robert Hofmeister, Holger Wesche, Werner Falk |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Receptor complex
Immunology Proteins Receptors Interleukin-1 Interleukin 1 receptor type II Biology Interleukin-1 receptor Transfection Molecular biology Endocytosis Cell biology Mice Interleukin 10 Interleukin-21 receptor Animals Interleukin-2 Immunology and Allergy RNA Messenger Signal transduction Interleukin-1 Receptor Accessory Protein Interleukin 1 receptor type I Cells Cultured Protease-activated receptor 2 Interleukin-1 Signal Transduction |
| Zdroj: | European Journal of Immunology. 27:262-267 |
| ISSN: | 1521-4141 0014-2980 |
| Popis: | Interleukin-1 (IL-1) is a central molecule in inflammation and immune responses whose pleiotropic activities are mediated by the type I IL-1 receptor (IL-1RI). The IL-1RI alone on the cell surface is silent after binding of the ligand. We show that the recently identified IL-1RI accessory protein (IL-1RAcP) converts the silent into a fully functional IL-1RI complex. Although transfection of IL-1RAcP into IL-1RAcP-deficient EL4D6/76 cells did not alter the binding kinetics or dissociation constants of the 125I-labeled IL-1alpha/IL-1RI complex, a very early event, internalization of the activated receptor complex, and a late event, IL-1-stimulated IL-2 production, were successfully restored. Therefore, recruitment of IL-1RAcP is a critical early step in the signaling cascade mediated by the IL-1RI activation complex. |
| Databáze: | OpenAIRE |
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