Effects of short-term cognitive-coping therapy on resting-state brain function in obsessive-compulsive disorder
| Autor: | Xunan Wang, Hong-Zeng Zhao, Zhi-Rong Li, Li-Jing Shi, Jian-Dong Ma, Shao-Jie Kou, Hong-Kai Lian, Xian-Zhang Hu, De-En Sang, Hengfen Li, Ping Huang, Chang-Hong Wang |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Obsessive-Compulsive Disorder genetic structures 050105 experimental psychology lcsh:RC321-571 Lingual gyrus 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Pharmacotherapy Cognition Gyrus Internal medicine Adaptation Psychological obsessive‐compulsive disorder Medicine Humans 0501 psychology and cognitive sciences lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Original Research Resting state fMRI medicine.diagnostic_test Cognitive Behavioral Therapy OCD treatment business.industry Postcentral gyrus Putamen 05 social sciences Brain psychotherapy medicine.anatomical_structure rs‐fMRI cognitive‐coping therapy Cardiology sense organs business Functional magnetic resonance imaging Insula 030217 neurology & neurosurgery |
| Zdroj: | Brain and Behavior Brain and Behavior, Vol 11, Iss 4, Pp n/a-n/a (2021) |
| ISSN: | 2162-3279 |
| Popis: | Background Obsessive‐compulsive disorder (OCD) tends to be treatment refractory. Recently, cognitive‐coping therapy (CCT) for OCD is reported to be an efficacious psychotherapy. However, the underlying neurophysiological mechanism remains unknown. Here, the effects of CCT on OCD and the resting‐state brain function were investigated. Methods Fifty‐nine OCD patients underwent CCT, pharmacotherapy plus CCT (pCCT), or pharmacotherapy. Before and after a 4‐week treatment, Yale‐Brown obsessive‐compulsive scale (Y‐BOCS) was evaluated and resting‐state functional magnetic resonance imaging (rs‐fMRI) was scanned. Results Compared with the baseline, significant reduction of Y‐BOCS scores was found after four‐week treatment (p This study investigated the effects of CCT on OCD and the resting‐state brain function were investigated in 59 OCD patients underwent CCT, pharmacotherapy plus CCT (pCCT), or pharmacotherapy. The effectiveness of CCT for OCD was related to the alteration of resting‐state brain function ‐ the brain plasticity. |
| Databáze: | OpenAIRE |
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