Neutrophil gelatinase-associated lipocalin (NGAL) predicts the occurrence of malaria-induced acute kidney injury
| Autor: | Dennis A. Hesselink, Liese C. Koopmans, Rob Koelewijn, Marlies E van Wolfswinkel, Ewout J. Hoorn, Perry J.J. van Genderen, Jaap J. van Hellemond |
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| Přispěvatelé: | Medical Microbiology & Infectious Diseases, Internal Medicine |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Plasmodium falciparum 030231 tropical medicine 030232 urology & nephrology Pilot Projects Urine urologic and male genital diseases Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Lipocalin-2 SDG 3 - Good Health and Well-being Predictive Value of Tests Internal medicine parasitic diseases medicine Humans Hepatitis A Virus Cellular Receptor 1 NGAL KIM-1 Malaria Falciparum Aged Netherlands Travel Creatinine Kidney biology Research Acute kidney injury Acute Kidney Injury Middle Aged Prognosis medicine.disease biology.organism_classification Malaria medicine.anatomical_structure Infectious Diseases chemistry Predictive value of tests Immunology Female Parasitology Complication |
| Zdroj: | Malaria Journal, 15. BioMed Central Ltd. Malaria Journal |
| ISSN: | 1475-2875 |
| DOI: | 10.1186/s12936-016-1516-y |
| Popis: | Background Acute kidney injury (AKI) is a frequently encountered complication of imported Plasmodium falciparum infection. Markers of structural kidney damage have been found to detect AKI earlier than serum creatinine-based prediction models but have not yet been evaluated in imported malaria. This pilot study aims to explore the predictive performance of neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) for AKI in travellers with imported P. falciparum infection. Methods Thirty-nine patients with imported falciparum malaria from the Rotterdam Malaria Cohort with available serum and urine samples at presentation were included. Ten of these patients met the criteria for severe malaria. The predictive performance of NGAL and KIM-1 as markers for AKI was compared with that of serum creatinine. Results Six of the 39 patients (15 %) developed AKI. Serum and urine NGAL and urine KIM-1 were all found to have large areas under the receiver operating characteristics curves (AUROC) for predicting AKI. Urine NGAL was found to have an excellent performance with positive predictive value (PPV) of 1.00 (95 % CI 0.54–1.00), a negative predictive value (NPV) of 1.00 (95 % CI 0.89–1.00) and an AUROC of 1.00 (95 % CI 1.00–1.00). Conclusion A good diagnostic performance of NGAL and KIM-1 for AKI was found. Particularly, urine NGAL was found to have an excellent predictive performance. Larger studies are needed to demonstrate whether these biomarkers are superior to serum creatinine as predictors for AKI in P. falciparum malaria. Electronic supplementary material The online version of this article (doi:10.1186/s12936-016-1516-y) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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