Cortical phase changes in Alzheimer's disease at 7T MRI: A novel imaging marker
| Autor: | Jeroen van der Grond, Mark A. van Buchem, Andrea B. Maier, Michael K. Liem, Ania M. Oleksik, Andrew G. Webb, Julien Milles, Sanneke van Rooden, Maarten J. Versluis |
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| Přispěvatelé: | Internal medicine, MOVE Research Institute, Neuromechanics, Research Institute MOVE |
| Rok vydání: | 2013 |
| Předmět: |
Male
Postmortem studies Pathology medicine.medical_specialty Epidemiology Image Processing Clinical Neurology Hippocampus Brain imaging Human 7T MRI Statistics Nonparametric Cellular and Molecular Neuroscience Computer-Assisted SDG 3 - Good Health and Well-being Developmental Neuroscience Neuroimaging Alzheimer Disease Cortex (anatomy) Alzheimer Disease/pathology 80 and over Image Processing Computer-Assisted medicine Humans Nonparametric AD pathology Aged Cerebral Cortex Aged 80 and over medicine.diagnostic_test Health Policy Statistics Phase changes Magnetic resonance imaging Biomarker Alzheimer's disease medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health medicine.anatomical_structure Cerebral cortex Biomarker (medicine) Female Neurology (clinical) Geriatrics and Gerontology Psychology Cerebral Cortex/pathology |
| Zdroj: | Alzheimers & Dementia, 10(1), e19-e26. Elsevier Alzheimers & Dementia, 10(1), e19-26. Elsevier Inc. van Rooden, S, Versluis, M J, Liem, M K, Milles, J, Maier, A B, Oleksik, A M, Webb, A G, van Buchem, M A & van der Grond, J 2014, ' Cortical phase changes in Alzheimer's disease at 7T MRI : a novel imaging marker ', Alzheimers & Dementia, vol. 10, no. 1, pp. e19-26 . https://doi.org/10.1016/j.jalz.2013.02.002 van Rooden, S, Versluis, M J, Liem, M K, Milles, J, Maier, A B, Oleksik, A M, Webb, A G, van Buchem, M A & van der Grond, J 2014, ' Cortical phase changes in Alzheimer's disease at 7T MRI: a novel imaging marker ', Alzheimers & Dementia, vol. 10, no. 1, pp. e19-e26 . https://doi.org/10.1016/j.jalz.2013.02.002 |
| ISSN: | 1552-5279 1552-5260 |
| Popis: | BACKGROUND: Postmortem studies have indicated the potential of high-field magnetic resonance imaging (MRI) to visualize amyloid depositions in the cerebral cortex. The aim of this study is to test this hypothesis in patients with Alzheimer's disease (AD).METHODS: T2*-weighted MRI was performed in 16 AD patients and 15 control subjects. All magnetic resonance images were scored qualitatively by visual assessment, and quantitatively by measuring phase shifts in the cortical gray matter and hippocampus. Statistical analysis was performed to assess differences between groups.RESULTS: Patients with AD demonstrated an increased phase shift in the cortex in the temporoparietal, frontal, and parietal regions (P < .005), and this was associated with individual Mini-Mental State Examination scores (r = -0.54, P < .05).CONCLUSION: Increased cortical phase shift in AD patients demonstrated on 7-tesla T2*-weighted MRI is a potential new biomarker for AD, which may reflect amyloid pathology in the early stages. |
| Databáze: | OpenAIRE |
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