Functionalization of Carbon Nanomaterial Surface by Doxorubicin and Antibodies to Tumor Markers
Autor: | Olga N. Bakalinska, Olena M. Perepelytsina, Mychailo V. Sydorenko, Luciano Rosario Maria Vicari, Olena M. Yakymchuk, Francesco Bloisi |
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Přispěvatelé: | Perepelytsina, Olena M., Yakymchuk, Olena M., Sydorenko, Mychailo V., Bakalinska, Olga N., Bloisi, Francesco, Vicari, LUCIANO ROSARIO MARIA |
Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
Drug
media_common.quotation_subject 02 engineering and technology 010402 general chemistry Bioinformatics 01 natural sciences Materials Science(all) Epidermal growth factor medicine polycyclic compounds Cytotoxic T cell General Materials Science Doxorubicin 87.15-v Functionalization media_common 87.64-t Nano Express biology Chemistry MAPLE deposition 61.48+c Onion-like carbons Biological macromolecules carbon nanomaterials matrix assisted pulsed laser evaporation 021001 nanoscience & nanotechnology medicine.disease Condensed Matter Physics Ultra dispersed diamonds Molecular medicine 61.48De 0104 chemical sciences carbohydrates (lipids) MCF-7 Cancer research biology.protein 61. 46+w Adenocarcinoma Antibody 0210 nano-technology medicine.drug |
Zdroj: | Nanoscale Research Letters |
Popis: | The actual task of oncology is effective treatment of cancer while causing a minimum harm to the patient. The appearance of polymer nanomaterials and technologies launched new applications and approaches of delivery and release of anticancer drugs. The goal of work was to test ultra dispersed diamonds (UDDs) and onion-like carbon (OLCs) as new vehicles for delivery of antitumor drug (doxorubicin (DOX)) and specific antibodies to tumor receptors. Stable compounds of UDDs and OLCs with DOX were obtained. As results of work, an effectiveness of functionalization was 2.94 % w/w for OLC-DOX and 2.98 % w/w for UDD-DOX. Also, there was demonstrated that UDD-DOX and OLC-DOX constructs had dose-dependent cytotoxic effect on tumor cells in the presence of trypsin. The survival of adenocarcinoma cells reduced from 52 to 28 % in case of incubation with the UDD-DOX in concentrations from 8.4-2.5 to 670-20 μg/ml and from 72 to 30 % after incubation with OLC-DOX. Simultaneously, antibodies to epidermal growth factor maintained 75 % of the functional activity and specificity after matrix-assisted pulsed laser evaporation deposition. Thus, the conclusion has been made about the prospects of selected new methods and approaches for creating an antitumor agent with capabilities targeted delivery of drugs. |
Databáze: | OpenAIRE |
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