Occurrence and neuroendocrine role ofD-aspartic acid andN-methyl-D-aspartic acid inCiona intestinalis

Autor: Patrizia Spinelli, Salvatore D'Aniello, Rakesh K. Rastogi, Antonietta De Simone, Maria Maddalena Di Fiore, Antimo D'Aniello, George H. Fisher, Margherita Branno, Francesco Aniello
Přispěvatelé: D'Aniello, A, Spinelli, P, De Simone, A, D'Aniello, S, Branno, M, Aniello, Francesco, Fisher, Gh, Di Fiore, Mm, Rastogi, Rk, DE SIMONE, A, Aniello, F, DI FIORE, Maria Maddalena, Antimo, D\'Aniello, Patrizia, Spinelli, ANTONIETTA DE, Simone, Salvatore, D\'Aniello, Margherita, Branno, Francesco, Aniello, Rastogi, RAKESH KUMAR, MARIA M., DI FIORE, RAKESH K., Rastogi
Rok vydání: 2003
Předmět:
Male
Invertebrate Hormones
Ciona intestinali
N-Methyl-D-aspartic acid
Gonadotropin-releasing hormone
Biochemistry
chemistry.chemical_compound
0302 clinical medicine
Structural Biology
D-Aspartic acid
Testosterone
Progesterone
0303 health sciences
ATP synthase
biology
Reproduction
Stereoisomerism
Ciona intestinalis
Protochordate
NMDA receptor
Female
hormones
hormone substitutes
and hormone antagonists
endocrine system
medicine.medical_specialty
N-Methylaspartate
Evolution
Biophysics
Aspartate racemase
In Vitro Techniques
03 medical and health sciences
Internal medicine
Genetics
medicine
Animals
Gonads
Molecular Biology
030304 developmental biology
Aspartic Acid
Cell Biology
biology.organism_classification
Neurosecretory Systems
Endocrinology
chemistry
biology.protein
030217 neurology & neurosurgery
Hormone
Zdroj: FEBS Letters. 552:193-198
ISSN: 0014-5793
DOI: 10.1016/s0014-5793(03)00921-9
Popis: Probes for the occurrence of endogenous D-aspartic acid (D-Asp) and N-methyl-D-aspartic acid (NMDA) in the neural complex and gonads of a protochordate, the ascidian Ciona intestinalis, have confirmed the presence of these two excitatory amino acids and their involvement in hormonal activity. A hormonal pathway similar to that which occurs in vertebrates has been discovered. In the cerebral ganglion D-Asp is synthesized from L-Asp by an aspartate racemase. Then, D-Asp is transferred through the blood stream into the neural gland where it gives rise to NMDA by means of an NMDA synthase. NMDA, in turn, passes from the neuronal gland into the gonads where it induces the synthesis and release of a gonadotropin-releasing hormone (GnRH). The GnRH in turn modulates the release and synthesis of testosterone and progesterone in the gonads, which are implicated in reproduction. © 2003 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
Databáze: OpenAIRE
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