Does a Reduction in the Glomerular Filtration Rate Increase the Overall Severity of Coronary Artery Stenosis?
| Autor: | Akiyoshi Hashimoto, Hirofumi Ohnishi, Akihito Tsuchida, Mina Kawamukai, Tetsuji Miura, Nobuaki Kokubu, Tohru Hasegawa, Yoshito Ohnuma, Hidemichi Kouzu, Junichi Nishida |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty 030232 urology & nephrology Renal function Comorbidity 030204 cardiovascular system & hematology Coronary Angiography Severity of Illness Index Coronary artery disease Angina 03 medical and health sciences Sex Factors 0302 clinical medicine Risk Factors Internal medicine Severity of illness Internal Medicine Humans Medicine Angina Stable Risk factor Aged Aged 80 and over business.industry Hemoglobin E Cholesterol HDL Smoking Age Factors Coronary Stenosis General Medicine Middle Aged medicine.disease Coronary Vessels Lipids Coronary arteries Stenosis medicine.anatomical_structure Multivariate Analysis Cardiology Female business Glomerular Filtration Rate Kidney disease |
| Zdroj: | Internal Medicine. 55:871-877 |
| ISSN: | 1349-7235 0918-2918 |
| Popis: | Objective Chronic kidney disease is a risk factor of coronary events, however, its impact on coronary artery stenosis has not yet been clarified with the use of a large database. We examined the association between a reduced glomerular filtration rate (GFR) and the overall severity of coronary stenosis. Methods We enrolled 1,150 patients [mean age, 68±12 (SD) years; 66.6% men] who consecutively underwent coronary angiography for suspected stable angina pectoris. The overall severity of stenosis in the coronary arteries was assessed by the Gensini score (GS), and its logarithmic values (log-GS) were used for statistical analyses since the GS does not follow a normal distribution. Results The log-GS was significantly larger in men than in women (2.5±1.5 vs. 1.9±1.7), while the estimated GFR (eGFR) and comorbidities were comparable between both sexes. A multivariate regression analysis indicated that age, smoking, eGFR, HDL-cholesterol and HbA1c were independent explanatory variables of the log-GS in men, although the eGFR explained only 1.2% of the log-GS variation. In women, the eGFR was not included in the significant explanatory variables shown by the multivariate analysis. However, the sex difference in the regression for the eGFR-log-GS relationship was not statistically significant. Conclusion A reduced eGFR is a significant, but minor, determinant of the overall severity of coronary artery stenosis in men and potentially women. |
| Databáze: | OpenAIRE |
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