Design and Engineering of Deimmunized Vaccinia Viral Vectors
| Autor: | Mariya Viskovska, Kevin Song |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
biology
Immunogenicity viruses Medicine (miscellaneous) neutralizing antibody Review immunogenicity Virology General Biochemistry Genetics and Molecular Biology Neutralization Epitope Virus Viral vector chemistry.chemical_compound chemistry lcsh:Biology (General) biology.protein deimmunization Oncolytic Virus Therapy complement Vaccinia Neutralizing antibody oncolytic vaccinia virus lcsh:QH301-705.5 |
| Zdroj: | Biomedicines Biomedicines, Vol 8, Iss 491, p 491 (2020) |
| ISSN: | 2227-9059 |
| Popis: | Vaccinia viral (VV) vectors are increasingly used in oncolytic virus therapy and vaccine development for cancer and infectious diseases. However, their effectiveness is hindered by the strong anti-viral immune response induced by the viral vector. In this review, we discuss the strategies to deimmunize vaccinia viral vector. One approach is to mask the virus from the neutralization antibody responses by mapping and eliminating of B-cell epitopes on the viral membrane proteins. The recombinant VVs contain one or more viral glycoproteins with mutations in the neutralizing antibody epitopes, resulting in viral escape from neutralization. In addition, a regulator of complement activation (e.g., CD55) can be expressed on the surface of the virus particle, leading to increased resistance to complement-mediated neutralization. |
| Databáze: | OpenAIRE |
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