Korean Red Ginseng reduces chronic social defeat stress-induced mood disorders via N-methyl-D-aspartate receptor modulation in mice
| Autor: | Seok-Yong Lee, Seong-Eon Kim, Boram Lee, Yong-Hyun Ko, Young-Jung Kim, Choon-Gon Jang, Seon-Kyung Kim, Ju-Hyun Lee, Kwang-Hyun Hur, Jee-Yeon Seo |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Elevated plus maze medicine.medical_specialty Receptor expression Anxiety Biochemistry Genetics and Molecular Biology (miscellaneous) Social defeat 03 medical and health sciences Ginseng Social avoidance 0302 clinical medicine lcsh:Botany Internal medicine medicine Hippocampus (mythology) Receptor business.industry Korean Red ginseng NMDA receptor medicine.disease lcsh:QK1-989 030104 developmental biology Endocrinology nervous system Complementary and alternative medicine Mood disorders 030220 oncology & carcinogenesis Chronic social defeat stress business Research Article Biotechnology |
| Zdroj: | Journal of Ginseng Research Journal of Ginseng Research, Vol 45, Iss 2, Pp 254-263 (2021) |
| ISSN: | 1226-8453 |
| Popis: | Background A chronic social defeat stress (CSDS) model has been proposed as relevant to stress-induced behavioral change in humans. In this study, we examined the effect of Korean Red Ginseng (KRG) on CSDS-induced mood disorders and protein expression in an animal model. Methods To evaluate the effect of KRG on social defeat stress, test mice were exposed in the resident aggressor's home cage compartment for 14 days beginning 1 h after KRG treatment (10, 20, and 40 mg/kg, per oral (p.o.)). After the exposure, behavioral tests to measure anxiety, social interaction, and depression-like behavior were performed. To investigate the underlying mechanism, N-methyl-D-aspartate receptor expression levels in CSDS-induced mice were evaluated using Western blot analysis. Results CSDS induced anxiety-like behaviors by decreasing central activity in the open-field test and open-arm approach in the elevated plus maze test and led to social avoidance behavior in the social interaction test. CSDS mice showed upregulated NR1, NR2A, and NR2B expression in the hippocampus. KRG 20 and 40 mg/kg ameliorated anxiety-like activities and KRG 20 mg/kg alleviated social avoidance by decreasing time in the corner zone. KRG treatment recovered CSDS-induced NR1, NR2A, and NR2B protein levels in the hippocampus. Conclusion These results indicate that KRG has a therapeutic effect on CSDS-induced mood disorder by alleviating N-methyl-D-aspartate receptor overexpression in the hippocampus. |
| Databáze: | OpenAIRE |
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