Retrospective Reconstructions of Active Bone Marrow Dose-Volume Histograms
| Autor: | Florent de Vathaire, Eric Quiniou, Jérémi Vu Bezin, Jean Pierre Mège, Jean Chavaudra, Rodrigue S. Allodji, Damien Llanas, Eric Deutsh, Dimitri Lefkopoulos, Cristina Veres, Ibrahima Diallo |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Cancer Research Time Factors Adolescent Matched-Pair Analysis Coefficient of variation medicine.medical_treatment Dose distribution Radiation Dosage Bone and Bones Standard deviation Bone Marrow Neoplasms Histogram Medical Illustration medicine Humans Radiology Nuclear Medicine and imaging Child Retrospective Studies Leukemia Radiation-Induced Radiation business.industry Age Factors Infant Middle Aged Radiation therapy medicine.anatomical_structure Oncology Density distribution Child Preschool Female Bone marrow business Nuclear medicine Volume (compression) |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 90:1216-1224 |
| ISSN: | 0360-3016 |
| Popis: | Purpose To present a method for calculating dose-volume histograms (DVH's) to the active bone marrow (ABM) of patients who had undergone radiation therapy (RT) and subsequently developed leukemia. Methods and Materials The study focuses on 15 patients treated between 1961 and 1996. Whole-body RT planning computed tomographic (CT) data were not available. We therefore generated representative whole-body CTs similar to patient anatomy. In addition, we developed a method enabling us to obtain information on the density distribution of ABM all over the skeleton. Dose could then be calculated in a series of points distributed all over the skeleton in such a way that their local density reflected age-specific data for ABM distribution. Dose to particular regions and dose-volume histograms of the entire ABM were estimated for all patients. Results Depending on patient age, the total number of dose calculation points generated ranged from 1,190,970 to 4,108,524. The average dose to ABM ranged from 0.3 to 16.4 Gy. Dose-volume histograms analysis showed that the median doses (D 50% ) ranged from 0.06 to 12.8 Gy. We also evaluated the inhomogeneity of individual patient ABM dose distribution according to clinical situation. It was evident that the coefficient of variation of the dose for the whole ABM ranged from 1.0 to 5.7, which means that the standard deviation could be more than 5 times higher than the mean. Conclusions For patients with available long-term follow-up data, our method provides reconstruction of dose-volume data comparable to detailed dose calculations, which have become standard in modern CT-based 3-dimensional RT planning. Our strategy of using dose-volume histograms offers new perspectives to retrospective epidemiological studies. |
| Databáze: | OpenAIRE |
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