Of the in vivo behavior of calcium phosphate cements and glasses as bone substitutes
| Autor: | J. A. Planell, Maria-Pau Ginebra, F. Macule, E.S. Sanzana, Melba Navarro, Santiago Suso |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Calcium Phosphates
Male Materials science Compressive Strength Biomedical Engineering chemistry.chemical_element Mineralogy Biocompatible Materials Calcium Biochemistry Osseointegration Phosphates Biomaterials chemistry.chemical_compound Potassium phosphate Animals Solubility Bone regeneration Molecular Biology Cement Bone Cements technology industry and agriculture General Medicine Phosphate Resorption Models Chemical chemistry Bone Substitutes Adsorption Glass Rabbits Biotechnology Nuclear chemistry |
| Zdroj: | Acta Biomaterialia. 4:1924-1933 |
| ISSN: | 1742-7061 |
| DOI: | 10.1016/j.actbio.2008.04.023 |
| Popis: | The use of injectable self-setting calcium phosphate cements or soluble glass granules represent two different strategies for bone regeneration, each with distinct advantages and potential applications. This study compares the in vivo behavior of two calcium phosphate cements and two phosphate glasses with different composition, microstructure and solubility, using autologous bone as a control, in a rabbit model. The implanted materials were alpha-tricalcium phosphate cement (cement H), calcium sodium potassium phosphate cement (cement R), and two phosphate glasses in the P(2)O(5)-CaO-Na(2)O and P(2)O(5)-CaO-Na(2)O-TiO(2) systems. The four materials were osteoconductive, biocompatible and biodegradable. Radiological and histological studies demonstrated correct osteointegration and substitution of the implants by new bone. The reactivity of the different materials, which depends on their solubility, porosity and specific surface area, affected the resorption rate and bone formation mainly during the early stages of implantation, although this effect was weak. Thus, at 4 weeks the degradation was slightly higher in cements than in glasses, especially for cement R. However, after 12 weeks of implantation all materials showed a similar degradation degree and promoted bone neoformation equivalent to that of the control group. |
| Databáze: | OpenAIRE |
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