Effect of probiotic supplementation on plasma metabolite profile after Roux-Y gastric bypass: a prospective, randomized, double-blind, placebo-controlled clinical trial

Autor: Marília Rizzon Zaparolli Ramos, Ingrid Felicidade, Lígia de Oliveira Carlos, Nathalia Ramori Farinha Wagner, Mário Sérgio Mantovani, Luan Vitor Alves de Lima, Lúcia Regina Ribeiro, Thiago Inácio Barros Lopes, Fernanda Carla Henrique-Bana, João Vitor Zimmerman, Fernando Cesar Macedo Junior, Magda Rosa Ramos da Cruz, Antônio Carlos Ligocki Campos
Rok vydání: 2022
Předmět:
Zdroj: International journal of obesity (2005). 46(11)
ISSN: 1476-5497
Popis: There is evidence that metabolic profile changes after Roux-Y gastric bypass (RYGB), especially due to modifications in the gastrointestinal tract. In addition, previous studies have suggested that probiotics can modify the microbiome and produce metabolites important for metabolic health maintenance. In this sense, the aim of this study was to verify the influence of probiotic supplementation on the plasma metabolite profile after RYGB.This was a randomized, double-blind, placebo-controlled clinical trial conducted with 31 patients subjected to RYGB surgery, randomized in probiotic group that was supplemented with a probiotic supplement (FloraVantageReductions in trimethylamine-N-oxide (TMAO) and alanine were observed in both groups, however this reduction was greater in the probiotic group (TMAO 13.82%, p = 0.01 and alanine 14.03%, p = 0.03) at T2. Additionally, β-hydroxybutyrate (BHB) levels increased 10.77% in the probiotic group (p = 0.03) compared to the placebo group at T2.Supplementation with Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 was able to associate with significant differences in relevant plasma metabolites associated with improved metabolic health.
Databáze: OpenAIRE
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