Plasma Osteoprotegerin Levels and Long-Term Prognosis in Patients With Intermediate Coronary Artery Lesions
| Autor: | Zening Jin, Fei Yuan, Yundai Chen, Fang Chen, Qingmiao Yang, Shu-zheng Lü, Hong Li, Xiantao Song, Yujie Zhou, Yong Huo |
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| Rok vydání: | 2011 |
| Předmět: |
Male
China medicine.medical_specialty Time Factors medicine.medical_treatment Clinical Investigations Coronary Angiography Revascularization Risk Assessment Severity of Illness Index Angina Osteoprotegerin Risk Factors Internal medicine Humans Medicine Prospective Studies Myocardial infarction Prospective cohort study Aged Proportional Hazards Models Chi-Square Distribution business.industry Hazard ratio Coronary Stenosis General Medicine Middle Aged Prognosis medicine.disease Survival Analysis Up-Regulation Quartile Cardiology Female Cardiology and Cardiovascular Medicine business Biomarkers Dyslipidemia |
| Zdroj: | Clinical Cardiology. 34:447-453 |
| ISSN: | 0160-9289 |
| Popis: | Background: Osteoprotegerin (OPG) is a member of the tumor necrosis factor superfamily and plays an important regulatory role in the skeletal, immune, and vascular systems. Intermediate coronary artery lesions that have a diameter stenosis of approximately 20%–70% might cause serious consequences. However, the prognostic value of plasma OPG levels in patients with intermediate coronary artery lesions has been less reported. Hypothesis: We hypothesized that OPG is a predictive marker of prognosis of intermediate coronary artery lesions. Methods: A prospective study was performed on 890 patients with intermediate (20%–70%) coronary lesions. The median age was 62 years (25th and 75th percentiles, 55 and 70 years, respectively) and 67.2% were male. Fasting blood was sampled at baseline. The primary clinical endpoint was a composite of readmission due to angina pectoris, nonfatal myocardial infarction, revascularization, and cardiovascular death. Results: During a median follow-up of 24 months, events occurred in 11.1% of the patients. Of these patients, 7.9% were readmitted for angina pectoris, 1.5% received revascularization, 0.7% suffered nonfatal myocardial infarction, and 1.0% died. The plasma levels of OPG (median, 5304.7 pg/mL vs 2993.4 pg/mL, P |
| Databáze: | OpenAIRE |
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