Ibuprofen overdose: 126 cases
| Autor: | Barry H. Rumack, Terry L Dwelle, Frances L. Conrad, Susan C. Smolinske, Kathleen M. Wruk, Kenneth W. Kulig, Alan H. Hall |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Bradycardia
Adult Central Nervous System Resuscitation Poison Control Centers Adolescent Apnea Ibuprofen Asymptomatic Blurred vision Seizures Ingestion Medicine Humans Depression (differential diagnoses) Dose-Response Relationship Drug business.industry Infant Anesthesia Child Preschool Emergency Medicine medicine.symptom business medicine.drug Half-Life |
| Zdroj: | Annals of emergency medicine. 15(11) |
| ISSN: | 0196-0644 |
| Popis: | In this study of ibuprofen overdose, symptoms developed in 19% of patients (24 of 126)--in 7% of children (6 of 88) and in 47% of adults (18 of 38). Central nervous system depression, seizures, gastrointestinal disturbances, bradycardia, hypotension, apnea, abnormal renal functions, hematuria, nystagmus, and blurred vision were observed. No patients became symptomatic more than four hours after ingestion. There was no significant difference (P greater than .05) between symptomatic and asymptomatic adult groups in either total milligrams or milligram-per-kilogram amounts ingested by history. Pediatric patients who became symptomatic had a mean ingestion by history of 440 mg/kg; those who remained asymptomatic had a mean ingestion by history of 114 mg/kg (P less than .001). No patients ingesting less than 99 mg/kg by history developed any symptoms. Two children had seizures or apnea and one died. Ibuprofen occasionally may cause serious toxicity in overdose. |
| Databáze: | OpenAIRE |
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