The effects of cholecystokinin octapeptide on human isolated alimentary muscle
| Autor: | Alan Bennett, I F Stamford, M. D'Amato |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Atropine
medicine.medical_specialty Colon Ileum Tetrodotoxin In Vitro Techniques Biology digestive system Sincalide Internal medicine Muscarinic acetylcholine receptor medicine Humans Large intestine Cholecystokinin Neurons Pharmacology Stomach digestive oral and skin physiology Muscle Smooth Acetylcholine Small intestine medicine.anatomical_structure Endocrinology medicine.symptom Digestive System hormones hormone substitutes and hormone antagonists Research Article Muscle Contraction medicine.drug Muscle contraction |
| Zdroj: | British Journal of Pharmacology. 100:126-130 |
| ISSN: | 0007-1188 |
| Popis: | 1. We studied cholecystokinin octapeptide (CCK-OP) for its motor effects and sites of action on human isolated muscle from stomach, small intestine and colon. 2. CCK-OP induced a concentration-dependent contraction of all the longitudinal muscles and of circular muscle from the stomach and large intestine. The peptide acted directly on these muscles at a site not involving muscarinic receptors. 3. CCK-OP relaxed the circular muscle of the small intestine and/or reduced the contractions to acetylcholine, by stimulating intramural postganglionic inhibitory neurones. |
| Databáze: | OpenAIRE |
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