Association of histological subtype with risk of recurrence in craniopharyngioma patients: a systematic review and meta-analysis
Autor: | Han Ding, Le Yang, Jie Wu, You Qing Yang, You Yuan Bao, Xiao Wu, Tao Hong, Lin Zhou, Chen Xing Yang |
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Rok vydání: | 2021 |
Předmět: |
medicine.medical_specialty
business.industry General Medicine Odds ratio medicine.disease Lower risk Gastroenterology Craniopharyngioma Confidence interval 030218 nuclear medicine & medical imaging 03 medical and health sciences Papillary craniopharyngioma 0302 clinical medicine Internal medicine Meta-analysis medicine Humans Pituitary Neoplasms Surgery Neurology (clinical) Neurosurgery business Pathological 030217 neurology & neurosurgery |
Zdroj: | Neurosurgical Review. 45:139-150 |
ISSN: | 1437-2320 0344-5607 |
DOI: | 10.1007/s10143-021-01563-9 |
Popis: | It is controversial whether there is a different risk of recurrence between two histological subtypes in craniopharyngioma (CP) patients. Some reported that adamantinomatous craniopharyngioma (ACP) had a higher risk of recurrence than papillary craniopharyngioma (PCP), but others reported that there is no significant difference between them. So, we conducted this systematic review and meta-analysis to determine the association between the histological subtype of CP and the rate of recurrence. A comprehensive literature search was undertaken in PubMed, EMBASE, and Web of Science for all English articles published up to November 2020. Recurrence data stratified by ACP and PCP were extracted from studies meeting inclusion criteria. A pooled analysis of the association between the histological subtype of craniopharyngioma and rates of recurrence was performed. Thirteen articles containing 974 patients were included. When stratified by two pathological subtypes, the total recurrence rate of ACP was 26.0% and PCP was 14.1%, which showed ACP associated with a higher risk of tumor recurrence than PCP (odds ratio [OR] = 2.12, 95% confidence interval [CI] = 1.36, 3.30, P = 0.00). This is the first meta-analysis focusing on histological subtypes of CP. PCP associates with a lower risk of recurrence than ACP, indicating that ACP could act as one of recurrence risk factors for CP patients. Nevertheless, large sample size and well-designed multicenter studies in which the other clinical variables are controlled to determine the histological subtype of CP as an independent recurrence risk factor are needed. |
Databáze: | OpenAIRE |
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