Systemic Delivery and Biodistribution of Cisplatin in Vivo
| Autor: | D. Thomas Dickey, Robert M. Strongin, Yu Hsuan Chu, Martha Sibrian-Vazquez, Qi Wang, Martina Ralle, Peter S. Steyger, Amanda R. Phillips, Jorge O. Escobedo |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Biodistribution medicine.medical_treatment Pharmaceutical Science Antineoplastic Agents Pharmacology Article Nephrotoxicity 03 medical and health sciences 0302 clinical medicine Ototoxicity In vivo Neoplasms Drug Discovery medicine Animals Humans Distribution (pharmacology) Cisplatin Chemotherapy Dose-Response Relationship Drug Chemistry medicine.disease 3. Good health 030104 developmental biology 030220 oncology & carcinogenesis Systemic administration Molecular Medicine medicine.drug |
| Zdroj: | Molecular Pharmaceutics. 13:2677-2682 |
| ISSN: | 1543-8392 1543-8384 |
| Popis: | Cisplatin is widely used to treat a variety of cancers. However, ototoxicity and nephrotoxicity remain serious side effects of cisplatin-based chemotherapy. In order to inform the study of cisplatin’s off-target effects, a new drug-fluorophore conjugate was synthesized that exhibited utility as a tracer to determine the cellular uptake and in vivo distribution of cisplatin. This probe will serve as a useful tool to facilitate investigations into the kinetics and biodistribution of cisplatin and its associated side effects in preclinical models after systemic administration. |
| Databáze: | OpenAIRE |
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