The development of a nucleus staining fluorescent probe for dynamic mitosis imaging in live cells
| Autor: | Jungyeol Lee, Krishna Kanta Ghosh, Dohee Kim, Nam-Young Kang, Jun-Young Kim, Jaeduk Yoo, Wan Si Yan Diana, Yun Kyung Kim, Yun-Mi Jeong, Young-Tae Chang |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Cell division
Xanthones Mitosis Catalysis chemistry.chemical_compound Materials Chemistry medicine Humans Fluorescent Dyes Cell Nucleus Staining and Labeling Chemistry Cell Cycle Metals and Alloys General Chemistry Triazoles Cell cycle Fluorescence Molecular biology Molecular Imaging Surfaces Coatings and Films Electronic Optical and Magnetic Materials Staining Cell biology medicine.anatomical_structure Long term monitoring Ceramics and Composites Nucleus DNA |
| Zdroj: | Chemical Communications. 51:9336-9338 |
| ISSN: | 1364-548X 1359-7345 |
| DOI: | 10.1039/c5cc02295a |
| Popis: | A low-toxicity nucleus staining fluorescent probe, CDb12, was developed for real time mitosis imaging in live cells. CDb12 was identified by unbiased high-throughput imaging-based screening of a new xanthone library (AX). Unlike the conventional Hoechst dye, the low toxicity of CDb12 allows long term monitoring of cell division over more than one cell cycle. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|