A Comparison of Yttrium-90 Microsphere Radioembolization to Hepatic Arterial Infusional Chemotherapy for Patients with Chemo-refractory Hepatic Colorectal Metastases

Autor: Vyacheslav Gendel, Marinela Capanu, John L. Nosher, Joanne F. Chou, Andrea Cercek, Salma K. Jabbour, Dirk F. Moore, Darren R. Carpizo, Chunxia Chen, Taryn M. Boucher, Nancy E. Kemeny
Rok vydání: 2017
Předmět:
Adult
Male
Oncology
medicine.medical_specialty
animal structures
Adolescent
medicine.medical_treatment
Infusional chemotherapy
Kaplan-Meier Estimate
Gastroenterology
Microsphere
Young Adult
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Hepatic arterial infusion
Refractory
Internal medicine
Regorafenib
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Infusions
Intra-Arterial
Yttrium Radioisotopes
Pharmacology (medical)
In patient
030212 general & internal medicine
Aged
Chemotherapy
business.industry
Liver Neoplasms
virus diseases
Middle Aged
Embolization
Therapeutic
Microspheres
Treatment Outcome
medicine.anatomical_structure
chemistry
Drug Resistance
Neoplasm
030220 oncology & carcinogenesis
Retreatment
Female
Radiopharmaceuticals
Colorectal Neoplasms
business
Follow-Up Studies
Artery
Zdroj: Current Treatment Options in Oncology. 18
ISSN: 1534-6277
1527-2729
DOI: 10.1007/s11864-017-0481-1
Popis: Patients with unresectable hepatic colorectal metastases who become chemo-refractory have limited treatment options. Systemic chemotherapies such as TAS102 and regorafenib have been used in the refractory setting, but with only modest improvement in overall survival compared to best supportive care. In patients with liver-only or liver-dominant disease, direct chemotherapy to the liver such as hepatic artery infusional (HAI) chemotherapy and radioembolization (yttrium-90 (Y90)) should be considered. Due to the difficulty of HAI therapy post Y90 for technical reasons, we recommend HAI therapy prior to Y90.
Databáze: OpenAIRE
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