High Firing Rate of Neonatal Hippocampal Interneurons Is Caused by Attenuation of Afterhyperpolarizing Potassium Currents by Tonically Active Kainate Receptors
| Autor: | Sari E. Lauri, Christophe Mulle, Tomi Taira, Juuso Juuri, Frederic Lanore, Mikael Segerstråle, Petteri Piepponen |
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| Přispěvatelé: | Physiologie cellulaire de la synapse (PCS), Université Bordeaux Segalen - Bordeaux 2-Institut François Magendie-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2010 |
| Předmět: |
Patch-Clamp Techniques
Potassium Tonic inhibition Action Potentials Glutamic Acid Hippocampus chemistry.chemical_element Kainate receptor In Vitro Techniques Biology Hippocampal formation Membrane Potentials Mice 03 medical and health sciences 0302 clinical medicine Receptors Kainic Acid GTP-Binding Proteins Interneurons Neural Pathways Animals 030304 developmental biology Mice Knockout 0303 health sciences musculoskeletal neural and ocular physiology General Neuroscience Glutamate receptor Afterhyperpolarization Articles CA3 Region Hippocampal Mice Inbred C57BL Animals Newborn nervous system chemistry [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] CA3 Stratum Lucidum Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neuroscience Journal of Neuroscience, Society for Neuroscience, 2010, 30, pp.6507-6514. ⟨10.1523/jneurosci.4856-09.2010⟩ |
| ISSN: | 1529-2401 0270-6474 |
| Popis: | In the neonatal hippocampus, the activity of interneurons shapes early network bursts that are important for the establishment of neuronal connectivity. However, mechanisms controlling the firing of immature interneurons remain elusive. We now show that the spontaneous firing rate of CA3 stratum lucidum interneurons markedly decreases during early postnatal development because of changes in the properties of GluK1 (formerly known as GluR5) subunit-containing kainate receptors (KARs). In the neonate, activation of KARs by ambient glutamate exerts a tonic inhibition of the medium-duration afterhyperpolarization (mAHP) by a G-protein-dependent mechanism, permitting a high interneuronal firing rate. During development, the amplitude of the apamine-sensitive K+currents responsible for the mAHP increases dramatically because of decoupling between KAR activation and mAHP modulation, leading to decreased interneuronal firing. The developmental shift in the KAR function and its consequences on interneuronal activity are likely to have a fundamental role in the maturation of the synchronous neuronal oscillations typical for adult hippocampal circuitry. |
| Databáze: | OpenAIRE |
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