Magnetic sensitivity of cryptochrome 4 from a migratory songbird
| Autor: | Patrick D. F. Murton, Joseph S. Takahashi, Jingjing Xu, Sabine Richert, Stuart R. Mackenzie, Lauren E. Jarocha, Rabea Bartölke, P. J. Hore, Ilia A. Solov'yov, Stefanie J. Käsehagen, Stefan Weber, Haijia Wu, Can Xie, Karl-Wilhelm Koch, Tommy L. Pitcher, Angela S. Gehrckens, Marco Bassetto, Maike Herrmann, Jessica Schmidt, Hang Yin, Jessica Fleming, Matthew J. Golesworthy, Jiate Luo, Yujing Wei, Daniel J. C. Sowood, Yogarany Chelliah, Gabriel Moise, Victoire Déjean, Glen Dautaj, Christiane R. Timmel, Henrik Mouritsen, Tilo M. Zollitsch, Jessica R. Walton, Marcin Konowalczyk, Kevin B. Henbest, Simon Horst |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Multidisciplinary Erithacus biology Chemistry biology.organism_classification European robin Retina 3. Good health Songbird Avian Proteins Cryptochromes Songbirds 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Magnetic Fields Cryptochrome biology.animal Biophysics Animals Animal Migration Columbidae Chickens 030217 neurology & neurosurgery |
| Zdroj: | Nature |
| ISSN: | 0028-0836 |
| DOI: | 10.1038/s41586-021-03618-9 |
| Popis: | Night-migratory songbirds are remarkably proficient navigators1. Flying alone and often over great distances, they use various directional cues including, crucially, a light-dependent magnetic compass2,3. The mechanism of this compass has been suggested to rely on the quantum spin dynamics of photoinduced radical pairs in cryptochrome flavoproteins located in the retinas of the birds4–7. Here we show that the photochemistry of cryptochrome 4 (CRY4) from the night-migratory European robin (Erithacus rubecula) is magnetically sensitive in vitro, and more so than CRY4 from two non-migratory bird species, chicken (Gallus gallus) and pigeon (Columba livia). Site-specific mutations of ErCRY4 reveal the roles of four successive flavin–tryptophan radical pairs in generating magnetic field effects and in stabilizing potential signalling states in a way that could enable sensing and signalling functions to be independently optimized in night-migratory birds. Cryptochrome 4 from the night-migratory European robin displays magnetically sensitive photochemistry in vitro, in which four successive flavin–tryptophan radical pairs generate magnetic-field effects and stabilize potential signalling states. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink