Prognosis of severe lymphopenia after postoperative radiotherapy in non-small cell lung cancer: Results of a long-term follow up study
| Autor: | Steven H. Lin, Zhongxing Liao, Yufei Liu, Hui Zhu, Aileen B. Chen, Michael S. O'Reilly, Percy Lee, Wang Jing, James W. Welsh, Joe Y. Chang, Melenda Jeter, Quynh Nhu Nguyen, Saumil Gandhi |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Long term follow up Lymphocyte Postoperative radiotherapy R895-920 Logistic regression Gastroenterology Article 030218 nuclear medicine & medical imaging 03 medical and health sciences Medical physics. Medical radiology. Nuclear medicine 0302 clinical medicine Non-small cell lung cancer immune system diseases hemic and lymphatic diseases Internal medicine Lymphopenia Medicine Radiology Nuclear Medicine and imaging Lung cancer neoplasms RC254-282 Lung business.industry Incidence (epidemiology) Neoplasms. Tumors. Oncology. Including cancer and carcinogens hemic and immune systems medicine.disease Prognosis respiratory tract diseases medicine.anatomical_structure Oncology Chemoradiation 030220 oncology & carcinogenesis Non small cell business |
| Zdroj: | Clinical and Translational Radiation Oncology, Vol 28, Iss, Pp 54-61 (2021) Clinical and Translational Radiation Oncology |
| ISSN: | 2405-6308 |
| Popis: | Highlights • First study to investigate lymphopenia in NSCLC with postoperative radiotherapy. • Radiation-induced lymphopenia is common is this population. • Lymphopenia is correlated with radiation fraction number and total mean lung dose. • Lymphopenia is an independent risk factor for PFS and OS, particularly in stage III NSCLC. Purpose To investigate the incidence and prognosis of severe radiation-induced lymphopenia (sRIL) after postoperative radiotherapy (PORT) for resected NSCLC. Patients and methods Between 1998 and 2017, 170 patients treated with PORT for NSCLC were retrospectively reviewed. Lymphopenia was divided into tertiles with severe lymphopenia defined as absolute lymphocyte counts (ALC) |
| Databáze: | OpenAIRE |
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