Food intake precipitates seizures in temporal lobe epilepsy
Autor: | Andreas Schulze-Bonhage, Dalma Tényi, Sára Jeges, József Janszky |
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Rok vydání: | 2021 |
Předmět: |
Adult
Male Food intake Adolescent Science Monitoring Ambulatory Physiology Article Temporal lobe Eating Young Adult Seizure onset Epilepsy Sex Factors Risk Factors Seizures Reflex Epilepsy Humans Medicine Child Aged Multidisciplinary business.industry Age Factors Infant Ictal eeg Electroencephalography Middle Aged medicine.disease Circadian Rhythm Epilepsy Temporal Lobe Neurology Child Preschool Epilepsy syndromes Reflex Female business |
Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
ISSN: | 2045-2322 |
DOI: | 10.1038/s41598-021-96106-z |
Popis: | Various factors have been considered as potential seizure precipitants. We here assessed the temporal association of food intake and seizure occurrence, and characteristics of seizures and epilepsy syndromes involved. 596 seizures from 100 consecutive patients undergoing long-term video-EEG monitoring were analyzed. Preictal periods of 60 min were assessed as to the occurrence of food intake, and latencies between food intake and seizure onset were analyzed. Seizures of temporal origin were highly significantly more frequently preceded by food intake compared to those of extratemporal origin; and were associated with shorter food intake-seizure latency. Seizure precipitation by food intake showed male predominance. Shorter food intake-seizure latency was associated with less severe seizures and less frequent contralateral spread of epileptic discharges. We here show for the first time that not only in specific rare reflex epilepsies but in the most frequent form of focal epilepsy, temporal lobe epilepsy, seizures are significantly precipitated by food intake. Seizure occurrence was increased over a period of up to one hour following food intake, and remained more localized in terms of both ictal EEG spread and as reflected by seizure severity. This finding supports the emerging concepts of ictogenesis, implying a continuum between reflex and spontaneous seizures—instead a dichotomy between them. |
Databáze: | OpenAIRE |
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