Oxidative stress-induced DNA damage and homocysteine accumulation may beinvolved in ovarian cancer progression in both young and old patients
| Autor: | Rafshan Sadiq, Kashaf Zafar, Sadia Javed, Shazia Anwer Bukhari, Muhammad Ibrahim Rajoka, Zubair Ibrahim |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Homocysteine DNA damage Antioxidants DNA damage CA-125 C-reactive protein malondialdehyde total antioxidant status total oxidative stress medicine.disease_cause Antioxidants 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Humans 030212 general & internal medicine Ovarian Neoplasms medicine.diagnostic_test biology business.industry C-reactive protein Cancer General Medicine Malondialdehyde medicine.disease Oxidative Stress Endocrinology chemistry Biochemistry 030220 oncology & carcinogenesis Erythrocyte sedimentation rate biology.protein Female Ovarian cancer business Oxidative stress DNA Damage |
| Zdroj: | Volume: 46, Issue: 3 583-589 Turkish Journal of Medical Sciences |
| ISSN: | 1300-0144 1303-6165 |
| Popis: | Background/aim: Biochemical, environmental, and genetic factors such as oxidative stress-induced DNA damage and homocysteine (Hcy) accumulation in the blood are involved in the development and progression of ovarian cancer. This study measured some biomarkers closely linked to the progression of ovarian cancer and also found their correlates. Materials and methods: Thirty patients were diagnosed with ovarian cancer using pelvic examination, transvaginal ultrasound, and cancer antibody (CA-125) measurement. Total oxidative stress (TOS), DNA damage, Hcy, malondialdehyde (MDA), total antioxidant status (TAS), and other biochemical parameters were determined. Results: TOS and DNA damage were positively and significantly correlated between themselves and were involved in causation of tumors as reflected by significantly (P < 0.001) higher CA-125, erythrocyte sedimentation rate (ESR), creatinine, and C-reactive protein (CRP) in both young and old patients. Both were significantly correlated with Hcy, LDL-cholesterol, alanine aminotransferase, aspartate aminotransferase, CRP, MDA, and CA-125. However, they were negatively correlated with TAS. Thus, excessive inflammation and oxidative stress caused an increase in DNA damage and enhanced Hcy content, leading to development of ovarian cancer. Conclusion: This study suggests the use of antioxidants as drugs to reduce oxidative stress, DNA damage, and other causes of cancer development |
| Databáze: | OpenAIRE |
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