Clinicopathological Significance of Vascular Endothelial Growth Factor-C in Breast Carcinoma with Long-Term Follow-Up
| Autor: | Masahiko Tsujimoto, Masaaki Nakahara, Kennichi Kakudo, Misa Nakamura, Yasushi Nakamura, Shigeru Imabun, Ayumi Tsukiyama, Ichiro Mori, Kazuyasu Nakao, Hironao Yasuoka, Qifeng Yang |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Oncology medicine.medical_specialty Pathology Time Factors Receptor ErbB-2 Vascular Endothelial Growth Factor C Breast Neoplasms Endothelial Growth Factors Disease-Free Survival Pathology and Forensic Medicine Breast cancer Internal medicine Biomarkers Tumor medicine Humans Lymph node Survival analysis Aged Aged 80 and over Univariate analysis business.industry Middle Aged Prognosis medicine.disease Immunohistochemistry Survival Analysis Lymphatic system medicine.anatomical_structure Receptors Estrogen Vascular endothelial growth factor C Lymphatic Metastasis Female Tumor Suppressor Protein p53 Receptors Progesterone business Breast carcinoma Follow-Up Studies |
| Zdroj: | Modern Pathology. 16:309-314 |
| ISSN: | 0893-3952 |
| DOI: | 10.1097/01.mp.0000062858.98295.9f |
| Popis: | Expression of angiogenic and lymphangiogenic factors by tumors may influence the route of metastatic spread. The angiogenic factor vascular growth factor-C (VEGF-C) is implicated in the development of lymphatic vessels and promotion of lymphatic metastasis. The purpose of this study was to determine whether VEGF-C correlates with lymph node metastasis or prognosis. We assessed VEGF-C expression using immunohistochemistry in 123 invasive breast carcinomas with long-term follow-up. The relationship between VEGF-C expression and lymph node status and other established clinicopathological parameters was assessed. Whether VEGF-C expression plays a prognostic role in breast cancer was also investigated. VEGF-C expression was identified in 103 cases (83.7%). Positive VEGF-C was significantly correlated with lymph node metastasis (P = 0.0131). Survival curves determined by the Kaplan-Meier method and univariate analysis demonstrated that positive VEGF-C was associated with both disease-free survival (P = 0.0165) and overall survival (P = 0.0175). On the basis of our findings, VEGF-C plays a crucial role in lymph node metastasis and may be a significant prognostic factor for long-term survival in breast cancer. |
| Databáze: | OpenAIRE |
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