Polymorphisms in the superoxidase dismutase genes reveal no association with human longevity in Germans: a case-control association study
| Autor: | Friederike Flachsbart, Liljana Gentschew, Almut Nebel, Rabea Kleindorp, Stefan Schreiber, Nandini Badarinarayan |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Aging media_common.quotation_subject Longevity SOD2 Single-nucleotide polymorphism Biology Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Superoxide Dismutase-1 Gene Frequency Germany Genetic variation SNP Humans 030304 developmental biology media_common Genetics Aged 80 and over 0303 health sciences Superoxide Dismutase Haplotype Phenotype Haplotypes Case-Control Studies Female Geriatrics and Gerontology Centenarian Gerontology 030217 neurology & neurosurgery |
| Zdroj: | Biogerontology; Vol 14 |
| ISSN: | 1573-6768 |
| Popis: | The role of superoxide dismutases (SODs) in aging and oxidative stress regulation has been widely studied and there is growing evidence that imbalances in these processes influence lifespan in several species. In humans, genetic polymorphisms in SOD genes may play an important role in the development of age-related diseases and genetic variation in SOD2 is thought to be associated with longevity. These observations prompted us to perform a case–control association study using a comprehensive haplotype tagging approach for the three SOD genes (SOD1, SOD2, SOD3) by testing a total of 19 SNPs in our extensive collection of 1,612 long-lived individuals (centenarians and nonagenarians) and 1,104 younger controls. Furthermore, we intended to replicate the previous association of the SOD2 SNP rs4880 with longevity observed in a Danish cohort. In our study, no association was detected between the tested SNPs and the longevity phenotype, neither in the entire long-lived sample set nor in the centenarian subgroup analysis. Our results suggest that there is no considerable influence of sequence variation in the SOD genes on human longevity in Germans. |
| Databáze: | OpenAIRE |
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