Changes in Hepatitis a Virus Seroepidemiology in Hiv-Infected Brazilian Patients
| Autor: | A.J. de Almeida, Ana Maria Coimbra Gaspar, V.S. De Paula, R Aloise, Carlos Alberto Morais-de-Sá, Fernando Samuel Sion |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Sexually transmitted disease Adolescent viruses HIV Infections Dermatology Hepatitis A Antibodies Virus Serology Cohort Studies Acquired immunodeficiency syndrome (AIDS) Humans Medicine Pharmacology (medical) Child Hepatitis Hepatitis A Vaccines business.industry fungi Public Health Environmental and Occupational Health Infant virus diseases Hepatitis A Middle Aged biochemical phenomena metabolism and nutrition medicine.disease Virology digestive system diseases Infectious Diseases Child Preschool Immunology Coinfection Female Hepatitis A virus Viral disease business Brazil |
| Zdroj: | International Journal of STD & AIDS. 19:321-326 |
| ISSN: | 1758-1052 0956-4624 |
| Popis: | Shifting of hepatitis A virus (HAV) epidemiology from a high towards an intermediate endemicity pattern and use of antiretroviral therapy increased the risk of HIV/HAV coinfection in developing countries. The aim of this study was to investigate the presence of HAV markers in a cohort of HIV-infected patients from 1988 to 2004. The presence of serum anti-HAV antibodies and HAV-RNA by real-time polymerase chain reaction was investigated in 581 patients. Total anti-HAV antibodies was found in 464/581 (79.8%) patients, however, achanging epidemiologic pattern of hepatitis A among HIV-infected patients from 1988 to 2004 was observed. Among patients susceptible to HAV ( n = 117), 5 (4.2%) were co-infected with HAV, all of them had IgM anti-HAV antibodies and were serum HAV-RNA-positive. The high prevalence of anti-HAV antibodies in HIV-infected patients suggests that screening tests for anti-HAV antibodies should be performed before implementation of hepatitis A vaccination, especially in those patients from endemic countries. |
| Databáze: | OpenAIRE |
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