Effects of a single dose of enrofloxacin on body temperature and tracheobronchial neutrophil count in healthy Thoroughbreds premedicated with interferon-α and undergoing long-distance transportation
| Autor: | Koji Sakamoto, Shoichi Narita, Takeru Tsuchiya, Yoshiro Endo, Seiji Hobo |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Neutrophils medicine.medical_treatment Respiratory System Rectum Transportation Body Temperature Leukocyte Count Anti-Infective Agents Interferon α medicine Enrofloxacin Animals Horses Saline Serum Amyloid A Protein General Veterinary business.industry Interferon-alpha General Medicine Surgery medicine.anatomical_structure Anesthesia Absolute neutrophil count Female business Fluoroquinolones medicine.drug |
| Zdroj: | American Journal of Veterinary Research. 73:968-972 |
| ISSN: | 0002-9645 |
| DOI: | 10.2460/ajvr.73.7.968 |
| Popis: | Objective—To evaluate effects of a single dose of enrofloxacin (5 mg/kg, IV) on body temperature and tracheobronchial neutrophil count in healthy Thoroughbreds premedicated with interferon-α and undergoing long-distance transportation. Animals—32 healthy Thoroughbreds. Procedures—All horses received interferon-α (0.5 U/kg, sublingually, q 24 h) as an immunologic stimulant for 2 days before transportation and on the day of transportation. Horses were randomly assigned to receive enrofloxacin (5 mg/kg, IV, once; enrofloxacin group) or saline (0.9% NaCl) solution (50 mL, IV, once; control group) ≤ 1 hour before being transported 1,210 km via commercial vans (duration, approx 26 hours). Before and after transportation, clinical examination, measurement of temperature per rectum, and hematologic analysis were performed for all horses; a tracheobronchial aspirate was collected for neutrophil quantification in 12 horses (6/group). Horses received antimicrobial treatment after transportation if deemed necessary by the attending clinician. Results—No adverse effects were associated with treatment. After transportation, WBC count and serum amyloid A concentration in peripheral blood samples and neutrophil counts in tracheobronchial aspirates were significantly lower in horses of the enrofloxacin group than in untreated control horses. Fever (rectal temperature, ≥ 38.5°C) after transportation was detected in 3 of 16 enrofloxacin group horses and 9 of 16 control horses; additional antimicrobial treatment was required in 2 horses in the enrofloxacin group and 7 horses in the control group. Conclusions and Clinical Relevance—In horses premedicated with interferon-α, enrofloxacin appeared to provide better protection against fever and lower respiratory tract inflammation than did saline solution. |
| Databáze: | OpenAIRE |
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