Resolution of Disseminated Angiosarcoma in a Kidney Transplant Recipient After Treatment With Sirolimus: A Case Report

Autor:	Jessica K. Friedman, Mohammad Atari, Kofi Atiemo, Adarsh Vijay, Hoonbae Jeon, Mary T. Killackey, Sixto Giusti, Anil S. Paramesh
Rok vydání:	2022
Předmět:	Sirolimus Graft Rejection Transplantation Hemangiosarcoma Humans Surgery Female Mycophenolic Acid Kidney Transplantation Immunosuppressive Agents Tacrolimus Aged
Zdroj:	Transplantation proceedings. 54(10)
ISSN:	1873-2623
Popis:	Angiosarcoma is a rare, almost universally fatal malignant neoplasm in kidney transplant recipients. No evidence-based guidelines are available for disseminated disease. Here, we report a case of a 66-year-old woman who developed disseminated angiosarcoma 4 months after living nonrelated kidney transplant. She underwent only 2 rounds of chemotherapy because of intolerable adverse effects. Her mycophenolic acid and tacrolimus were withdrawn and sirolimus use was started. In addition to its immunosuppressant effects, sirolimus has been shown to have antineoplastic properties. Remarkably, at almost 2 years post-transplant, the patient has had complete resolution of all gross metastatic disease with only immunosuppressant medication changes. This case highlights the interesting possibility that sirolimus is an effective adjunct treatment for disseminated angiosarcoma in kidney transplant recipients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed0a6361a95bed2d9c21c44853d86f2 https://pubmed.ncbi.nlm.nih.gov/36443108 Zobrazit plný text záznamu Full Text from ScienceDirect