Effects of Glycyrrhizic acid on 11 β-Hydroxysteroid Dehydrogenase (11 βHSD1 and 2) Activities and HOMA-IR in Rats at Different Treatment Periods
| Autor: | Y Y, Chia, Y Y, Yin, S H, Ton, K B A, Kadir |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Endocrinology Diabetes and Metabolism medicine.medical_treatment Anti-Inflammatory Agents Drug Evaluation Preclinical Blood sugar Adipose tissue Biology Rats Sprague-Dawley chemistry.chemical_compound Endocrinology Insulin resistance Diabetes mellitus 11-beta-Hydroxysteroid Dehydrogenase Type 2 Internal medicine Adipocytes Internal Medicine medicine Animals Homeostasis Saline Cell Size Kidney Glycogen Insulin General Medicine 11 β hydroxysteroid dehydrogenase Glycyrrhizic Acid medicine.disease Rats Enzyme Activation Postprandial medicine.anatomical_structure chemistry 11-beta-Hydroxysteroid Dehydrogenases Insulin Resistance Injections Intraperitoneal |
| Zdroj: | Experimental and Clinical Endocrinology & Diabetes. 118:617-624 |
| ISSN: | 1439-3646 0947-7349 |
| DOI: | 10.1055/s-0029-1237703 |
| Popis: | Glycyrrhizic acid (GA) has been reported to inhibit postprandial blood glucose rise and 11 β-hydroxysteroid dehydrogenase 1 (11 βHSD1) activity. As not much work has been done on GA effects on 11 βHSD1 and 2 and HOMA-IR at different treatment periods, this work was conducted. 60 male Sprague Dawley rats fed AD LIBITUM were assigned into six groups of control and treated that were given GA at different duration namely 12, 24 and 48 h. Treated and control groups were intraperitoneally administered with GA (50 mgkg (-1)) and saline respectively. Blood and subcutaneous (ATS) and visceral adipose tissue (ATV), abdominal (MA) and quadriceps femoris muscle (MT), liver (L) and kidney (K) were examined. HOMA-IR in GA-treated rats decreased in all groups (P0.05). In the 12-h and 24-h treated rats, 11 βHSD1 activities decreased in all tissues (P0.05) except MA and MT (P0.05) in the former and ATV (P0.05) in the latter. However, 11 βHSD1 activities decreased significantly in all tissues ( P0.05) in the 48-h treated rats. Significant decrease in 11 βHSD2 (P0.05) activities were observed in the L of all treatment groups and K in the 24-h and 48-h treated rats (P0.05). Histological analysis on ATS showed increase in the number of small-size adipocytes while ATV adipocytes showed shrinkage after GA administration. Increased glycogen deposition in the L was observed in the GA-administered rats in all the treatment periods. In conclusion, GA treatment showed a decrease in the HOMA-IR and both 11 βHSD1 and 2 activities in all tissues, with more profound decrease in the 48-h treated rats. |
| Databáze: | OpenAIRE |
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