ERK-Mediated Mechanochemical Waves Direct Collective Cell Polarization
| Autor: | Kazuhiro Aoki, Leone Rossetti, Xavier Trepat, Michiyuki Matsuda, Ariadna Marín-Llauradó, Tsuyoshi Hirashima, Naoya Hino |
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| Rok vydání: | 2020 |
| Předmět: |
MAPK/ERK pathway
Kinase Contraction (grammar) Mechanotransduction Cell Biochemistry Mechanotransduction Cellular Forces Madin Darby Canine Kidney Cells 0302 clinical medicine Cell Movement Cell polarity Fret Biomechanics Epidermal growth factor receptor Phosphorylation Migration 0303 health sciences collective cell migration Wave propagation Chemistry Cell Polarity Cell biology ErbB Receptors medicine.anatomical_structure Adhesion mechanochemical feedback Intracellular Bioquímica MAP Kinase Signaling System EGFR DISTINCT ROLES Activation wave propagation Biology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Dogs intercellular signal transfer Rho medicine Extracellular Animals Molecular Biology mechanotransduction 030304 developmental biology ERK/MAPK front-rear polarity Polarity Egfr Biomecànica Cell Biology Biophysics biology.protein FRET 030217 neurology & neurosurgery mathematical model Developmental Biology |
| Zdroj: | Dipòsit Digital de la UB Universidad de Barcelona |
| Popis: | During collective migration of epithelial cells, the migration direction is aligned over a tissue-scale expanse. Although the collective cell migration is known to be directed by mechanical forces transmitted via cell-cell junctions, it remains elusive how the intercellular force transmission is coordinated with intracellular biochemical signaling to achieve collective movements. Here, we show that intercellular coupling of extracellular signal-regulated kinase (ERK)-mediated mechanochemical feedback yields long-distance transmission of guidance cues. Mechanical stretch activates ERK through epidermal growth factor receptor (EGFR) activation, and ERK activation triggers cell contraction. The contraction of the activated cell pulls neighboring cells, evoking another round of ERK activation and contraction in the neighbors. Furthermore, anisotropic contraction based on front-rear polarization guarantees unidirectional propagation of ERK activation, and in turn, the ERK activation waves direct multicellular alignment of the polarity, leading to long-range ordered migration. Our findings reveal that mechanical forces mediate intercellular signaling underlying sustained transmission of guidance cues for collective cell migration. 分子活性の波が細胞集団に伝わる制御機構を解明 --細胞同士の綱引きが情報を遠くに伝える--. 京都大学プレスリリース. 2020-06-04. Cells communicate by doing the 'wave'. 京都大学プレスリリース. 2020-07-22. |
| Databáze: | OpenAIRE |
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