Host-Gut Microbiota Crosstalk in Intestinal Adaptation
| Autor: | Justine Marchix, Michael A. Helmrath, Gillian Goddard |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Enteric Flora SBR small bowel resection Review Biology Gut flora SFB segmented filamentous bacteria Bioinformatics Microbial Metabolites Resection Intestinal Failure IF intestinal failure SBS short-bowel syndrome 03 medical and health sciences 0302 clinical medicine Mediator PN parenteral nutrition GLP-2 glucagon-like peptide 2 Intestinal failure IBD - Inflammatory bowel disease NEC necrotizing enterocolitis ENS enteric nervous system Hepatology IBD inflammatory bowel disease Gastroenterology biology.organism_classification GI gastrointestinal CONV conventional IL interleukin Crosstalk (biology) GF germ-free 030104 developmental biology Parenteral nutrition ICR ileocecal resection TGR5 Takeda-G-protein-receptor 5 Immune System SCFA short-chain fatty acid Adaptive Responses 030211 gastroenterology & hepatology Gut homeostasis |
| Zdroj: | Cellular and Molecular Gastroenterology and Hepatology |
| ISSN: | 2352-345X |
| Popis: | Short-bowel syndrome represents the most common cause of intestinal failure and occurs when the remaining intestine cannot support fluid and nutrient needs to sustain adequate physiology and development without the use of supplemental parenteral nutrition. After intestinal loss or damage, the remnant bowel undergoes multifactorial compensatory processes, termed adaptation, which are largely driven by intraluminal nutrient exposure. Previous studies have provided insight into the biological processes and mediators after resection, however, there still remains a gap in the knowledge of more comprehensive mechanisms that drive the adaptive responses in these patients. Recent data support the microbiota as a key mediator of gut homeostasis and a potential driver of metabolism and immunomodulation after intestinal loss. In this review, we summarize the emerging ideas related to host-microbiota interactions in the intestinal adaptation processes. |
| Databáze: | OpenAIRE |
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