Iodine-catalyzed oxidative functionalization of purines with (thio)ethers or methylarenes for the synthesis of purin-8-one analogues
| Autor: | Juanping Zhuge, Gary Histand, Dongen Lin, Ziyang Jiang, Wei Jiang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
inorganic chemicals
Chemistry Organic Chemistry chemistry.chemical_element Thio Oxidative phosphorylation Iodine Biochemistry Combinatorial chemistry Catalysis chemistry.chemical_compound Functional group Surface modification heterocyclic compounds Physical and Theoretical Chemistry Purine metabolism |
| Zdroj: | Organicbiomolecular chemistry. 19(23) |
| ISSN: | 1477-0539 |
| Popis: | An efficient oxidative functionalization of purine-like substrates with (thio)ethers or methylarenes under mild conditions is described. Using I2 as the catalyst, and TBHP as the oxidant, this protocol provides a valuable synthetic tool for the assembly of a wide range of 9-alkyl(benzyl)purin-8-one derivatives with high atom- and step-economy and exceptional functional group tolerance. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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