Novel mucoadhesive nasal inserts based on chitosan/hyaluronate polyelectrolyte complexes for peptide and protein delivery
| Autor: | Vittorio Zecchi, Milena Sorrenti, Federica Bigucci, Barbara Luppi, Laura Mercolini, Laura Catenacci, Alessandro Musenga |
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| Přispěvatelé: | B. Luppi, F. Bigucci, L. Mercolini, A. Musenga, M. Sorrenti, L. Catenacci, V. Zecchi |
| Rok vydání: | 2009 |
| Předmět: |
POLYELECTROLYTE COMPLEXES
NASAL ADMINISTRATION Pharmaceutical Science Mucous membrane of nose Peptide Chitosan chemistry.chemical_compound Drug Delivery Systems Vancomycin Adhesives Spectroscopy Fourier Transform Infrared Hyaluronic acid Mucoadhesion medicine Insulin MUCOADHESION Hyaluronic Acid Administration Intranasal Pharmacology chemistry.chemical_classification Chromatography Viscosity Proteins Water Hydrogen-Ion Concentration Polyelectrolyte Nasal Mucosa chemistry Thermogravimetry Immunology Nasal administration Swelling medicine.symptom Peptides |
| Zdroj: | Journal of Pharmacy and Pharmacology. 61:151-157 |
| ISSN: | 2042-7158 0022-3573 |
| Popis: | Objectives The purpose of this study was the preparation and characterisation of mucoadhesive nasal inserts based on chitosan/hyaluronate polyelectrolyte complexes prepared at various pHs and at different molar ratios. Methods A suspension of chitosan/hyaluronate complexes with or without the model drugs (vancomycin or insulin) was lyophilised into small inserts. Complexation yield, FT-IR spectra and thermogravimetric analysis were used to study the degree of interactive strength between polyions. In-vitro swelling, mucoadhesion and release tests were performed in order to investigate delivery of vancomycin and insulin in the nasal cavity. Key findings The results indicated that the selection of complex preparative conditions allows modulation of insert swelling and mucoadhesion ability. Nasal inserts containing vancomycin or insulin had showed completely different drug release behaviour. Conclusions Chitosan/hyaluronate polyelectrolyte complexes can be used for the formulation of mucoadhesive nasal inserts for the delivery of peptide and protein drugs. |
| Databáze: | OpenAIRE |
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