Identification of 4-hydroxyandrost-4-ene-3,17-dione metabolites in prostatic cancer patients by liquid chromatography—mass spectrometry
| Autor: | R. McCague, Wilfried M. A. Niessen, C. E. M. Heeremans, R.A.M. van der Hoeven, J. van der Greef, G.K. Poon, M. Jarman, J.H. Davies |
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| Rok vydání: | 1992 |
| Předmět: |
Male
Magnetic Resonance Spectroscopy Chromatography Metabolite medicine.medical_treatment Androstenedione Prostatic Neoplasms Thermospray Cancer General Chemistry Urine Mass spectrometry medicine.disease Mass Spectrometry Steroid chemistry.chemical_compound chemistry Liquid chromatography–mass spectrometry medicine Humans Spectrophotometry Ultraviolet Chromatography High Pressure Liquid Ene reaction |
| Zdroj: | Journal of Chromatography B: Biomedical Sciences and Applications. 576:235-244 |
| ISSN: | 0378-4347 |
| DOI: | 10.1016/0378-4347(92)80197-x |
| Popis: | Liquid chromatography with thermospray mass spectrometry has proved to be an invaluable technique for the study of metabolic degradation of xenobiotics in complex biological fluids. This paper describes the detection of 4-hydroxyandrost-4-ene-3,17-dione and its metabolites in urinary extracts from prostatic cancer patients. Several metabolites were detected including 4 beta,5 alpha-dihydroxyandrostan-3,17-dione, 3,17-dihydroxyandrostan-4-ones and 3 alpha-hydroxy-5 beta-androstan-4,17-dione. |
| Databáze: | OpenAIRE |
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