Teratogenic potential of cocaine hydrochloride in CF-1 mice
| Autor: | Michael P. Mahalik, David E. Mann, Ronald F. Gautieri |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Male
medicine.medical_specialty Pharmaceutical Science Gestational Age Gestation period Pharmacology Bone and Bones Mice Sex Factors Cocaine Pregnancy Cocaine toxicity Internal medicine medicine Animals Cocaine hydrochloride Eye Abnormalities Maternal-Fetal Exchange Fetus business.industry Abnormalities Drug-Induced Gestational age Fetal Resorption medicine.disease Teratology Teratogens Endocrinology embryonic structures Gestation Female business |
| Zdroj: | Journal of Pharmaceutical Sciences. 69:703-706 |
| ISSN: | 0022-3549 |
| DOI: | 10.1002/jps.2600690625 |
| Popis: | This investigation revealed that cocaine hydrochloride was teratogenic when administered in nontoxic doses to gravid CF-1 mice on Days 7-12 of gestation. The teratogenic susceptibility of the CF-1 mouse fetus to cocaine hydrochloride was evident throughout this portion of the gestation period. The early appearance of eye defects and the occurrence of skeletal defects later in gestation after cocaine hydrochloride challenge paralleled the sequence of ontogenesis. |
| Databáze: | OpenAIRE |
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