Sensitive imaging of magnetic nanoparticles for cancer detection by active feedback MR
| Autor: | Lian-Pin Hwang, Chao Hsiung Hsu, Dennis W. Hwang, Zhao Li, Hsin Wei Chang, Nikolay V. Dimitrov, Yung-Ya Lin |
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| Rok vydání: | 2015 |
| Předmět: |
Larmor precession
Zeeman effect Materials science medicine.diagnostic_test Quantitative Biology::Tissues and Organs Physics::Medical Physics Magnetic resonance imaging equipment and supplies Imaging phantom symbols.namesake Dipole Magnetization Nuclear magnetic resonance symbols medicine Magnetic nanoparticles Radiology Nuclear Medicine and imaging Molecular imaging human activities |
| Zdroj: | Magnetic Resonance in Medicine. 74:33-41 |
| ISSN: | 0740-3194 |
| Popis: | Purpose Sensitive imaging of superparamagnetic nanoparticles or aggregates is of great importance in MR molecular imaging and medical diagnosis. For this purpose, a conceptually new approach, termed active feedback magnetic resonance, was developed. Methods In the presence of the Zeeman field, a dipolar field is induced by the superparamagnetic nanoparticles or aggregates. Such dipolar field creates spatial and temporal (due to water diffusion) variations to the precession frequency of the nearby water 1H magnetization. Sensitive imaging of magnetic nanoparticles or aggregates can be achieved by manipulating the intrinsic spin dynamics by selective self-excitation and fixed-point dynamics under active feedback fields. Results Phantom experiments of superparamagnetic nanoparticles; in vitro experiments of brain tissue with blood clots; and in vivo mouse images of colon cancers, with and without labeling by magnetic nanoparticles, suggest that this new approach provides enhanced, robust, and positive contrast in imaging magnetic nanoparticles or aggregates for cancer detection. Conclusion The spin dynamics originated from selective self-excitation and fixed-point dynamics under active feedback fields have been shown to be sensitive to dipolar fields generated by magnetic nanoparticles. Magn Reson Med 74:33–41, 2015. © 2014 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
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