Low maternal serum levels of pregnancy associated plasma protein A (PAPP-A) in the first trimester in association with abnormal fetal karyotype
| Autor: | J.G. Grudzinskas, M. C. M. Macintosh, L. Tului, A. Lanzani, T. Chard, K. Shrimanker, S.D. Maguiness, B. Teisner, I. Bonacchi, Bruno Brambati |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
medicine.medical_specialty Down syndrome Pregnancy-associated plasma protein A Chorionic villus sampling Chromosome Disorders Trisomy Pregnancy Prenatal Diagnosis medicine Humans Pregnancy-Associated Plasma Protein-A Genetic Testing Retrospective Studies Chromosome Aberrations Gynecology Fetus medicine.diagnostic_test Obstetrics business.industry Pregnancy Outcome Obstetrics and Gynecology Retrospective cohort study Middle Aged medicine.disease Pregnancy Trimester First Chorionic Villi Sampling Karyotyping Gestation Female Down Syndrome Chromosomes Human Pair 18 business |
| Zdroj: | BJOG: An International Journal of Obstetrics & Gynaecology. 100:324-326 |
| ISSN: | 1470-0328 |
| DOI: | 10.1111/j.1471-0528.1993.tb12973.x |
| Popis: | Objective To assess the relation between maternal serum pregnancy associated plasma protein A (PAPP-A) in the first trimester and the outcome of pregnancy by karyotype. Design A retrospective study of PAPP-A levels in blood samples collected prior to chorionic villus sampling. Setting Milan, Italy. Subjects Five hundred twenty-two women, aged 20 to 47, at 7 to 11 weeks gestation, prior to undergoing chorionic villus sampling. Four hundred forty-five women had a pregnancy with a normal karyotype; in 30 pregnancies the karyotype was abnormal (including 14 cases of Down's syndrome and 7 of trisomy 18). Main outcome measures Normal or abnormal fetal karyotype. Serum PAPP-A at 6 to 11 weeks gestation measured by radioimmunoassay. Results The median value of PAPP-A in the abnormal group was 0.27 multiples of the normal median (MoM). This is significantly lower than the median value in the normal group (1.01 MoM) (95% CI for the difference 0.46–0.84 MoM; P |
| Databáze: | OpenAIRE |
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