Cancer mortality and incidence following external occupational radiation exposure: an update of the 3rd analysis of the UK national registry for radiation workers
| Autor: | Nezahat Hunter, Richard Haylock, Michael Gillies, Wei Zhang, Mary Phillipson |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Cancer Research Neoplasms Radiation-Induced Radiation Dosage Risk Assessment Article 030218 nuclear medicine & medical imaging Cohort Studies 03 medical and health sciences symbols.namesake Cancer epidemiology 0302 clinical medicine Epidemiology of cancer Humans Medicine Registries Poisson regression Mortality business.industry Incidence Incidence (epidemiology) Middle Aged United Kingdom Occupational Diseases Risk factors Oncology 030220 oncology & carcinogenesis Relative risk Cohort symbols Female National registry Risk assessment business Demography Cohort study |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | Background This study provides direct evidence of cancer risk from low dose and dose rate occupational external radiation exposures. Methods Cancer mortality and incidence were studied in relation to external radiation exposure in the National Registry for Radiation Workers. A cohort of 167,003 workers followed for an average of 32 years was analysed using Poisson regression methods. Results Mortality and incidence risks were significantly raised for the group of all malignant neoplasms excluding leukaemia (ERR/Sv mortality = 0.28; 90%CI: 0.06, 0.53, ERR/Sv incidence = 0.28; 90%CI: 0.10, 0.48) but with narrower confidence bounds compared with the previous analysis of this cohort reflecting the increased statistical power from the additional 10 years of follow-up information. The linear trends in relative risk for both mortality and incidence of these cancers remained statistically significantly raised when information relating to cumulative doses above 100 mSv was excluded (ERR/Sv mortality = 1.42; 90%CI: 0.51, 2.38 and ERR/Sv incidence = 1.18; 90%CI: 0.47, 1.92). Conclusions This study improved the precision of the cancer risk estimates seen in the third analysis of the NRRW cohort. The overall results remain consistent with the risk estimates from the Life Span Study and those adopted in the current ICRP recommendations. |
| Databáze: | OpenAIRE |
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